The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.
about
The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70-Tim44.Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complexJ protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix.Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane.Tim9, a new component of the TIM22.54 translocase in mitochondriaMitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role.Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins.Strong precursor-pore interactions constrain models for mitochondrial protein importBiology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function.Mitochondrial protein import and human health and disease.Endoplasmic Reticulum Stress Enhances Mitochondrial Metabolic Activity in Mammalian Adrenals and Gonads.Role of membrane contact sites in protein import into mitochondria.Unfolding of preproteins upon import into mitochondria.Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins.The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation.The intermembrane space domain of mitochondrial Tom22 functions as a trans binding site for preproteins with N-terminal targeting sequences.Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes.Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis.The J-related segment of tim44 is essential for cell viability: a mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation.A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase.Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteinsC- to N-terminal translocation of preproteins into mitochondriaThe role and significance of potential lipid-binding regions in the mitochondrial protein import motor: an in-depth in silico study.Redox Aspects of Chaperones in Cardiac Function.
P2860
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P2860
The nucleotide exchange factor MGE exerts a key function in the ATP-dependent cycle of mt-Hsp70-Tim44 interaction driving mitochondrial protein import.
description
1996 nî lūn-bûn
@nan
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
The nucleotide exchange factor ...... mitochondrial protein import.
@ast
The nucleotide exchange factor ...... mitochondrial protein import.
@en
The nucleotide exchange factor ...... mitochondrial protein import.
@nl
type
label
The nucleotide exchange factor ...... mitochondrial protein import.
@ast
The nucleotide exchange factor ...... mitochondrial protein import.
@en
The nucleotide exchange factor ...... mitochondrial protein import.
@nl
prefLabel
The nucleotide exchange factor ...... mitochondrial protein import.
@ast
The nucleotide exchange factor ...... mitochondrial protein import.
@en
The nucleotide exchange factor ...... mitochondrial protein import.
@nl
P2093
P2860
P1433
P1476
The nucleotide exchange factor ...... mitochondrial protein import.
@en
P2093
B Westermann
H C Schneider
P2860
P304
P407
P577
1996-11-01T00:00:00Z