about
Antigenic variation in Trypanosoma brucei: joining the DOTsGenome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFsA novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expressionAF10-dependent transcription is enhanced by its interaction with FLRGA higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcriptionHistone methyltransferase MLL1 regulates MDR1 transcription and chemoresistanceLinking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)Structural basis of the recognition of a methylated histone tail by JMJD2ANegative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes.Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancersAf9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortexA decade of exploring the cancer epigenome - biological and translational implicationsMicroRNA-126 regulates HOXA9 by binding to the homeoboxDOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cellsThe Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteinsTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesThe many faces of histone H3K79 methylationTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyEpigenetic regulators and their impact on therapy in acute myeloid leukemiaThe complexity of epigenetic diseasesSynthesis of lysine methyltransferase inhibitorsEpigenomics of leukemia: from mechanisms to therapeutic applicationsStructural and functional coordination of DNA and histone methylationRecent progress toward epigenetic therapies: the example of mixed lineage leukemiaEpigenetic regulators as promising therapeutic targets in acute myeloid leukemiaHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionHijacked in cancer: the KMT2 (MLL) family of methyltransferasesRegulation of αENaC transcriptionHaematopoietic malignancies caused by dysregulation of a chromatin-binding PHD fingerChemogenetic analysis of human protein methyltransferasesSelective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic StudiesPotent inhibition of DOT1L as treatment of MLL-fusion leukemiaConformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1LMultiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatinEpigenetic regulation of the intestinal epitheliumDiverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegansMisguided transcriptional elongation causes mixed lineage leukemiaThe histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structureThe leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
hDOT1L links histone methylation to leukemogenesis.
@ast
hDOT1L links histone methylation to leukemogenesis.
@en
hDOT1L links histone methylation to leukemogenesis.
@nl
type
label
hDOT1L links histone methylation to leukemogenesis.
@ast
hDOT1L links histone methylation to leukemogenesis.
@en
hDOT1L links histone methylation to leukemogenesis.
@nl
prefLabel
hDOT1L links histone methylation to leukemogenesis.
@ast
hDOT1L links histone methylation to leukemogenesis.
@en
hDOT1L links histone methylation to leukemogenesis.
@nl
P2093
P921
P3181
P1433
P1476
hDOT1L links histone methylation to leukemogenesis.
@en
P2093
Guoliang Xu
Vernon M Coffield
Yaqiang Li
Yuki Okada
P304
P3181
P356
10.1016/J.CELL.2005.02.020
P407
P577
2005-04-22T00:00:00Z