DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells - Test2 - elhamkhani - TriplyDB

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

http://www.wikidata.org/entity/Q24655388

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Chromatin landscape dictates HSF binding to target DNA elements The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer Overexpression of Cancer-Associated Genes via Epigenetic Derepression Mechanisms in Gynecologic Cancer Antigenic variation in Trypanosoma brucei: joining the DOTs A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation Combinatorial patterns of histone acetylations and methylations in the human genome Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives The many faces of histone H3K79 methylation Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.Multiple levels of epigenetic control for bone biology and pathology Misguided transcriptional elongation causes mixed lineage leukemia The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy Modeling gene expression using chromatin features in various cellular contexts Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1).Genome-wide epigenetic data facilitate understanding of disease susceptibility association studies.Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers.Histone modification levels are predictive for gene expression In vivo residue-specific histone methylation dynamics.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.Myogenic differential methylation: diverse associations with chromatin structure.Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation

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DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

http://www.wikidata.org/entity/Q24655388

description

2008 nî lūn-bûn

@nan

2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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type

label

DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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prefLabel

DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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Molecular and Cellular Biology

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DOT1L/KMT4 recruitment and H3K ...... anscription in mammalian cells

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Adam L Vakoc

http://www.w3.org/2001/XMLSchema#string

David J Steger

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David Zhuo

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Gerd A Blobel

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Ja-Eun Kim

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Junjie Chen

http://www.w3.org/2001/XMLSchema#string

Lei Ying

http://www.w3.org/2001/XMLSchema#string

Martina I Lefterova

http://www.w3.org/2001/XMLSchema#string

Michael Schupp

http://www.w3.org/2001/XMLSchema#string

Mitchell A Lazar

http://www.w3.org/2001/XMLSchema#string

P2860

Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

The human PAF complex coordinates transcription with events downstream of RNA synthesis.

Global and Hox-specific roles for the MLL1 methyltransferase

Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes

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2825-39

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scholarly article

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686524

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10.1128/MCB.02076-07

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8

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28

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Aaron Stonestrom

Christopher R. Vakoc

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2008-04-01T00:00:00Z

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5567649

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18285465

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2293113

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