Mechanical devices of the spliceosome: motors, clocks, springs, and things.
about
Cwc24p is a general Saccharomyces cerevisiae splicing factor required for the stable U2 snRNP binding to primary transcriptsThe human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 proteinThe snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factorThe subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicingCharacterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gemsSpecific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirusProtein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferaseTargeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodiesA subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicingPurification and characterization of native spliceosomes suitable for three-dimensional structural analysis.RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoproteinsSNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assemblyRNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodiesThe human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosomeHuman U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recyclingCwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centreCharacterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box proteinDistinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosomeBiochemical characterization of the ATPase and helicase activity of UAP56, an essential pre-mRNA splicing and mRNA export factorFunctional organization of the Sm core in the crystal structure of human U1 snRNPIsolation and characterization of post-splicing lariat-intron complexesStructure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assemblyGrowth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56Comparative genomics and evolution of proteins involved in RNA metabolismCUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motifFunctional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNAStimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assemblyThe 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesHierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteinsSMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome.SMN interacts with a novel family of hnRNP and spliceosomal proteinsPrp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNAA cyclophilin functions in pre-mRNA splicingProteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.RNA splicing capability of live neuronal dendrites
P2860
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P2860
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
description
1998 nî lūn-bûn
@nan
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@ast
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@en
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@nl
type
label
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@ast
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@en
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@nl
prefLabel
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@ast
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@en
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@nl
P3181
P1433
P1476
Mechanical devices of the spliceosome: motors, clocks, springs, and things.
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)80925-3
P407
P577
1998-02-06T00:00:00Z