The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein
about
RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodiesMolecular architecture of the human Prp19/CDC5L complexNuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicingNuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)Interaction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55kProteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.Prp8 protein: at the heart of the spliceosomePrp8p dissection reveals domain structure and protein interaction sites.The human Prp8 protein is a component of both U2- and U12-dependent spliceosomesCharacterization of U6 snRNA-protein interactions.Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiaePSF and p54nrb bind a conserved stem in U5 snRNAThe network of protein-protein interactions within the human U4/U6.U5 tri-snRNPPre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctionsHaploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephalyA complementation method for functional analysis of mammalian genesCryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feastStructure and function of an RNase H domain at the heart of the spliceosomeCrystal structure of Prp8 reveals active site cavity of the spliceosomeStructural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteA noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 proteinMolecular architecture of the human U4/U6.U5 tri-snRNPStructure of a yeast activated spliceosome at 3.5 Å resolutionAssembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationprp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeastPrp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function.Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing systemA functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in DrosophilaA general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.Nuclear DNA helicase II/RNA helicase A binds to filamentous actin.Mutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosaRoles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy.The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K proteinConserved loop I of U5 small nuclear RNA is dispensable for both catalytic steps of pre-mRNA splicing in HeLa nuclear extracts.A spliceosomal intron in Giardia lamblia.Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation
P2860
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P248
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P2860
The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@ast
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@en
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@en-gb
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@nl
type
label
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@ast
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@en
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@en-gb
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@nl
prefLabel
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@ast
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@en
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@en-gb
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@nl
P2093
P2860
P921
P356
P1476
The human U5-220kD protein (hP ...... F-2, and a novel WD-40 protein
@en
P2093
P2860
P304
P356
10.1128/MCB.18.11.6756
P407
P577
1998-11-01T00:00:00Z