A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
about
Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphatesDiscovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt familyThe synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinaseGle1 functions during mRNA export in an oligomeric complex that is altered in human diseaseThe mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translationInteraction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.Signal-dependent membrane targeting by pleckstrin homology (PH) domainsKaryopherin beta 2B participates in mRNA export from the nucleus.Regulation of chromatin remodeling by inositol polyphosphatesPhosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor ITargeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivoRoles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processesRegulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphateThe acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphateRegulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeuticsAn essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolismInositol hexakisphosphate is bound in the ADAR2 core and required for RNA editingYeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus.The emerging roles of inositol pyrophosphates in eukaryotic cell physiologyPhosphoinositides: tiny lipids with giant impact on cell regulationEffect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsrStructure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognitionStructural Studies and Protein Engineering of Inositol Phosphate MultikinaseSubstrate Binding in Protein-tyrosine Phosphatase-like Inositol PolyphosphatasesThe inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis.In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth.Phospholipase C is involved in kinetochore function in Saccharomyces cerevisiaeDistinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics.Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export.Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmanninControl of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1.Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.The yeast Apq12 protein affects nucleocytoplasmic mRNA transport.Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae.The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity.
P2860
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P2860
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
A phospholipase C-dependent in ...... fficient messenger RNA export.
@ast
A phospholipase C-dependent in ...... fficient messenger RNA export.
@en
A phospholipase C-dependent in ...... fficient messenger RNA export.
@nl
type
label
A phospholipase C-dependent in ...... fficient messenger RNA export.
@ast
A phospholipase C-dependent in ...... fficient messenger RNA export.
@en
A phospholipase C-dependent in ...... fficient messenger RNA export.
@nl
prefLabel
A phospholipase C-dependent in ...... fficient messenger RNA export.
@ast
A phospholipase C-dependent in ...... fficient messenger RNA export.
@en
A phospholipase C-dependent in ...... fficient messenger RNA export.
@nl
P2093
P3181
P1433
P1476
A phospholipase C-dependent in ...... fficient messenger RNA export.
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.285.5424.96
P407
P577
1999-07-02T00:00:00Z