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Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent mannerProteasome inhibition by fellutamide B induces nerve growth factor synthesisApplied techniques for mining natural proteasome inhibitorsStructures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism.Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilumInvestigations on the maturation and regulation of archaebacterial proteasomesA plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanismUbiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionStructural Analysis of Spiro β-Lactone Proteasome InhibitorsSynthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibitionStructure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reductionSnapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibitionProbing the reaction mechanism of IspH protein by x-ray structure analysis20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95ABiosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspGElucidation of the α-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibitionDiscovery of acetylene hydratase activity of the iron–sulphur protein IspHReverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)Synthesis and biological activity of optimized belactosin C congenersOne-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitorAlternative bacterial two-component small heat shock protein systemsCrystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesisHydroxyureas as noncovalent proteasome inhibitorsStructures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspHIncorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like SitesCrystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysisThe architecture of functional modules in the Hsp90 co-chaperone Sti1/HopInsights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) ProteinImmuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificityHigh-resolution structures of the IgM Fc domains reveal principles of its hexamer formationStructural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triadAre Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic InvestigationActivity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cellsDNA minor groove sensing and widening by the CCAAT-binding complexBiosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5Å resolutionInsights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspHThe structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulinsDimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasomeDifferential global structural changes in the core particle of yeast and mouse proteasome induced by ligand bindingStructure and reaction mechanism of pyrrolysine synthase (PylD)
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Michael Groll
@ast
Michael Groll
@en
Michael Groll
@es
Michael Groll
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type
label
Michael Groll
@ast
Michael Groll
@en
Michael Groll
@es
Michael Groll
@sl
prefLabel
Michael Groll
@ast
Michael Groll
@en
Michael Groll
@es
Michael Groll
@sl