Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
about
Pseudomonas syringae pv. syringae uses proteasome inhibitor syringolin A to colonize from wound infection sitesBiosynthesis of the proteasome inhibitor syringolin A: the ureido group joining two amino acids originates from bicarbonate.Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones.The impact of plant-pathogen studies on medicinal drug discovery.Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.Recent advances in proteasome inhibitor discovery.Mechanism of action of thalassospiramides, a new class of calpain inhibitorsSyrbactin Structural Analog TIR-199 Blocks Proteasome Activity and Induces Tumor Cell Death.Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464.The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.From bortezomib to other inhibitors of the proteasome and beyond.Activity-based imaging probes of the proteasome.The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins).Probes for activity-based profiling of plant proteases.Exploiting nature's rich source of proteasome inhibitors as starting points in drug development.Synthesis and pharmacology of proteasome inhibitors.Peptide-based proteasome inhibitors in anticancer drug design.Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesisSyringolin B-inspired proteasome inhibitor analogue TIR-203 exhibits enhanced biological activity in multiple myeloma and neuroblastoma.SylC catalyzes ureido-bond formation during biosynthesis of the proteasome inhibitor syringolin A.N-acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbF.Impact of the structures of macrocyclic Michael acceptors on covalent proteasome inhibition.Activity-Based Protein Profiling with Natural Product-Derived Chemical Probes in Human Cell Lysates.Total synthesis of syringolin A and improvement of its biological activity.Immunoproteasome inhibition and bioactivity of thiasyrbactins.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.GvmR - A Novel LysR-Type Transcriptional Regulator Involved in Virulence and Primary and Secondary Metabolism of Burkholderia pseudomallei.A New Highly Versatile Handle for Chemistry on a Solid Support: The Pipecolic Linker
P2860
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P2860
Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Synthetic and structural studi ...... tency of proteasome inhibition
@ast
Synthetic and structural studi ...... tency of proteasome inhibition
@en
Synthetic and structural studi ...... tency of proteasome inhibition
@nl
type
label
Synthetic and structural studi ...... tency of proteasome inhibition
@ast
Synthetic and structural studi ...... tency of proteasome inhibition
@en
Synthetic and structural studi ...... tency of proteasome inhibition
@nl
prefLabel
Synthetic and structural studi ...... tency of proteasome inhibition
@ast
Synthetic and structural studi ...... tency of proteasome inhibition
@en
Synthetic and structural studi ...... tency of proteasome inhibition
@nl
P2093
P2860
P356
P1476
Synthetic and structural studi ...... tency of proteasome inhibition
@en
P2093
André S Bachmann
Barbara Schellenberg
Damir J Illich
Jérôme Clerc
Markus Kaiser
Robert Dudler
Robert Huber
P2860
P304
P356
10.1073/PNAS.0901982106
P407
P577
2009-04-21T00:00:00Z