LRRK2 at the interface of autophagosomes, endosomes and lysosomes - Test2 - elhamkhani - TriplyDB

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

http://www.wikidata.org/entity/Q28078248

about

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice.Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease.The LRRK2 signalling system.Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases.Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease.Mutations in LRRK2 amplify cell-to-cell protein aggregate propagation: a hypothesis.The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.Modeling Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

P2860

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P2860

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

http://www.wikidata.org/entity/Q28078248

description

2016 nî lūn-bûn

@nan

2016 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2016 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

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name

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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type

label

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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Molecular Neurodegeneration

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LRRK2 at the interface of autophagosomes, endosomes and lysosomes

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Dorien A. Roosen

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Creative Commons Attribution 4.0 International

P2860

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

Ubiquitin is phosphorylated by PINK1 to activate parkin

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

The synaptic vesicle cycle

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export

LRRK2 transport is regulated by its novel interacting partner Rab32

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

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s13024-016-0140-1

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73

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scholarly article

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10.1186/S13024-016-0140-1

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1

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2016-12-07T00:00:00Z

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1001311533

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27927216

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P921

Parkinson's disease

Parkinson disease associated proteins

P932

5142374

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