Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP - Test2 - elhamkhani - TriplyDB

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

http://www.wikidata.org/entity/Q24293723

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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies Interplay of LRRK2 with chaperone-mediated autophagy Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease Hax-1 identified as a two-pore channel (TPC)-binding protein Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease Mitochondria: A Therapeutic Target for Parkinson's Disease?The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Autophagy and neurodegeneration Protein degradation pathways in Parkinson's disease: curse or blessing Upstream deregulation of calcium signaling in Parkinson's disease Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis Parkinson's disease and immune system: is the culprit LRRKing in the periphery?Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime Dysregulation of autophagy and mitochondrial function in Parkinson's disease LRRK2 at the interface of autophagosomes, endosomes and lysosomes Autophagosome dynamics in neurodegeneration at a glance Two-pore channels at the intersection of endolysosomal membrane traffic Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy Inhibition of LRRK2 kinase activity stimulates macroautophagy TPC: the NAADP discovery channel?Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease Two-pore channels (TPCs): current controversies mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1 Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Two-Pore Channels and Parkinson's Disease: Where's the Link?Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.Function and dysfunction of two-pore channels.The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.

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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

http://www.wikidata.org/entity/Q24293723

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

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2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

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name

Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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type

label

Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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prefLabel

Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Human Molecular Genetics

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Leucine-rich repeat kinase 2 r ...... endent pathway involving NAADP

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Berta Luzón-Toro

http://www.w3.org/2001/XMLSchema#string

Dev Churamani

http://www.w3.org/2001/XMLSchema#string

Duncan Bloor-Young

http://www.w3.org/2001/XMLSchema#string

Grant C Churchill

http://www.w3.org/2001/XMLSchema#string

Ling Zhang

http://www.w3.org/2001/XMLSchema#string

Patricia Gómez-Suaga

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Philip G Woodman

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Creative Commons Attribution-NonCommercial 3.0 Unported

P2860

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Role of AMP-activated protein kinase in mechanism of metformin action

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

Regulation of autophagy by the inositol trisphosphate receptor

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

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511-25

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1420114

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10.1093/HMG/DDR481

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3

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21

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Sabine Hilfiker

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2012-02-01T00:00:00Z

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51731779

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22012985

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positive regulation of autophagy

Two pore segment channel 2

Two pore segment channel 1

Protein kinase AMP-activated catalytic subunit alpha 1

Leucine rich repeat kinase 2

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3259011

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