Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties
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Radicals: Reactive Intermediates with Translational PotentialPractical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization.Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications.Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.The nuclear genome of Rhazya stricta and the evolution of alkaloid diversity in a medically relevant clade of Apocynaceae.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Natural Products and Their Mimics as Targets of Opportunity for Discovery.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.Natural product analogues: towards a blueprint for analogue-focused synthesis.Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.Indole diterpenoid natural products as the inspiration for new synthetic methods and strategiesThe Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Expression of tabersonine 16-hydroxylase and 16-hydroxytabersonine-O-methyltransferase in Catharanthus roseus hairy roots.Strategies to diversify natural products for drug discovery.High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs.Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent.One-Pot Aminoethylation of Indoles/Pyrroles with Alkynes and Sulfonyl Azides.Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums† †Electronic supplementary information (ESI) available: Experimental procedures and characterisation data for all compounds are provided. CCDC 1Synthesis and Study of the Antimalarial Cardamom Peroxide
P2860
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P2860
Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
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name
Total synthesis of vinblastine ...... structure-function properties
@ast
Total synthesis of vinblastine ...... structure-function properties
@en
Total synthesis of vinblastine ...... structure-function properties
@nl
type
label
Total synthesis of vinblastine ...... structure-function properties
@ast
Total synthesis of vinblastine ...... structure-function properties
@en
Total synthesis of vinblastine ...... structure-function properties
@nl
prefLabel
Total synthesis of vinblastine ...... structure-function properties
@ast
Total synthesis of vinblastine ...... structure-function properties
@en
Total synthesis of vinblastine ...... structure-function properties
@nl
P2860
P3181
P356
P1476
Total synthesis of vinblastine ...... structure-function properties
@en
P2093
Dale L. Boger
Justin E. Sears
P2860
P304
P3181
P356
10.1021/AR500400W
P407
P577
2015-03-17T00:00:00Z