Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues - Test2 - elhamkhani - TriplyDB

Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues

Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues

http://www.wikidata.org/entity/Q35836622

about

Azidation in the Difunctionalization of Olefins Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties Organic chemistry. Practical olefin hydroamination with nitroarenes Radicals: Reactive Intermediates with Translational Potential Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenes Functionalized olefin cross-coupling to construct carbon-carbon bonds.Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.Total synthesis of (-)-kopsinine and ent-(+)-kopsinine New insights into the mechanism and an expanded scope of the Fe(III)-mediated vinblastine coupling reaction.Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications.A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives.Total synthesis of kopsinine.Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates.Practical carbon-carbon bond formation from olefins through nickel-catalyzed reductive olefin hydrocarbonation.Catalytic Enantioselective Dihalogenation and the Selective Synthesis of (-)-Deschloromytilipin A and (-)-Danicalipin A.Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.General approach to the synthesis of the chlorosulfolipids danicalipin A, mytilipin A, and malhamensilipin A in enantioenriched form.Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation.Simple, chemoselective hydrogenation with thermodynamic stereocontrol.A practical and catalytic reductive olefin coupling.Catalysis of Radical Reactions: A Radical Chemistry Perspective.Markovnikov free radical addition reactions, a sleeping beauty kissed to life.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Palladium-catalyzed intramolecular reductive olefin hydrocarbonation: benzylic hydrogen serving as a new hydrogen donor.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.Ph(i-PrO)SiH2: An Exceptional Reductant for Metal-Catalyzed Hydrogen Atom Transfers.Hydromethylation of Unactivated Olefins.Amine synthesis via iron-catalysed reductive coupling of nitroarenes with alkyl halides.Iron-Catalyzed Direct Diazidation for a Broad Range of Olefins.Simple, chemoselective, catalytic olefin isomerization Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.Four-step synthesis of the antimalarial cardamom peroxide via an oxygen stitching strategy.Fe-Catalyzed C-C Bond Construction from Olefins via Radicals.Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)3 and NaBH4.Development of a concise synthesis of ouabagenin and hydroxylated corticosteroid analogues.

P2860

Q26753058-07C7B360-8A02-4040-80D6-1388609B3D80 Q28081042-B7E704B5-F666-4207-B539-DE540976C38D Q28262290-1F08139E-0C9A-481C-A13D-97805DD36386 Q28468198-D1F87619-5370-4127-A385-DB326FDCF9AF Q34292142-2C3F9933-4700-4808-8AC0-F1E2689DDD46 Q34742652-91928B37-00B3-4B42-A3C3-0C049DBDFD1B Q35504479-7FCC6BAA-D8CB-4A2A-85AF-DCAD1DE792CC Q35703917-34E988E6-29CD-419F-BD46-DB684A6A21BC Q36196869-8EC7B321-419A-43DB-A25D-8E19D291088C Q36259559-5F1F7EB0-1778-40F7-9100-6F740C8C1FF0 Q36561874-8F971C9C-4392-4C7C-A677-77D72D6B836C Q36586413-7EEBA101-9C40-4FF4-8228-3AD4F8F909DE Q36615003-A1221BC9-45F9-4D64-9090-BB7B580CA6AF Q36627224-62F3E83D-3586-46ED-BAE8-C2D1832AF032 Q36714576-1A2A6410-A30F-4803-A251-71E06D7BE24D Q36768656-30598DA8-0943-4AD9-9EE3-269D2C28ADD7 Q37042095-ADD248FF-4B12-47BA-BC58-5EBD3A3B8590 Q37258490-E11D4426-6825-459C-A950-DDAEA45149FF Q37291949-9BF93A56-4066-4BED-ADAD-C671946479A6 Q37624423-27864BF8-B0A1-410C-995B-76F1F73C24D9 Q37636527-93AC47FA-555D-4810-8C6D-C270BAD954B5 Q37637645-E7D9DC45-B7E6-4C6E-85CC-007078431312 Q37701729-6E4D0D33-4656-4145-88A7-EE82F41CA93F Q38259114-7B451BCD-C360-4105-A889-FD5755E4D74A Q38579982-21053746-44BB-4C5F-960B-EA7E5C1EF30E Q38605492-42D91940-2479-4F4C-BF31-7B70398F6299 Q38692671-6D86EB53-4170-4471-B673-D0AD2F5A0B5F Q38693705-3DBB9834-745F-4360-BF0A-473E8EC3EE91 Q38733720-DFF227CF-ED3A-40A0-A0DB-FEF12EBA5A9B Q38909626-E0F9E3B2-F201-448E-B84B-1828AA2F59AB Q41065106-435DDED9-851F-4051-944E-970FDE9930E8 Q41447701-43416C87-CCC5-4342-BD4D-2BAA2CD62477 Q41574159-219BFCA1-2E86-4730-8A6B-7F4F5845B52A Q41855560-6C75FCAC-9CED-4481-BD55-349B505C5600 Q41878500-0FC4ABD8-E8D5-48A2-95AA-52541C6D6ADA Q42108336-FD239D5C-C63E-4781-BEC1-BF823F419233 Q42132703-C15CB103-A45F-4357-8BE1-9354F51CE30A Q42320893-4DEF7740-D193-4639-AA02-F6ECE83EC3CF Q43107609-945CF0B7-70B1-4F82-A5B2-807A9CC0B762 Q43179938-2E9C5695-EB58-40C9-8FCE-62797276BFC2

P2860

Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues

http://www.wikidata.org/entity/Q35836622

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Iron(III)/NaBH4-mediated addit ...... ovel 20'-vinblastine analogues

@ast

Iron(III)/NaBH4-mediated addit ...... ovel 20'-vinblastine analogues

@en

type

label

Iron(III)/NaBH4-mediated addit ...... ovel 20'-vinblastine analogues

@ast

Iron(III)/NaBH4-mediated addit ...... ovel 20'-vinblastine analogues

@en

prefLabel

Iron(III)/NaBH4-mediated addit ...... ovel 20'-vinblastine analogues

@ast

Iron(III)/NaBH4-mediated addit ...... ovel 20'-vinblastine analogues

@en

P1433

Q35836622-D67AF571-67A3-4D52-8FE3-B1DE9EB91008

P1476

Q35836622-3FA08180-351F-40DB-B2CB-74B3B6C1349B

P2093

Q35836622-1DF47B78-AD79-4CCB-B88F-7AC0837DF133

Q35836622-51091242-4129-4440-9F1A-4C5E56EEEE8F

Q35836622-A6408104-A39A-4A23-86BF-79CE8F2CC396

Q35836622-A7BD7C35-7307-416E-AF8B-2115F9FEE541

P2860

Q35836622-25CA383F-01B2-4C5A-9C86-E946949DD365

Q35836622-30411B7C-820B-425D-8AD1-B00B5C3CC93E

Q35836622-4221CB20-4B3A-429C-97A5-B6926AE10EC5

Q35836622-5E555C93-4681-47FF-9452-9753FFC6CA7B

Q35836622-65542311-1DF8-486E-92FD-16BC9DD681DE

Q35836622-6DB9F1A3-374A-4177-8BC3-208341699379

Q35836622-7517FEFC-8ED4-412E-A0FC-52C358804DC3

Q35836622-A8AF0216-2ACF-4965-B691-9AEEF8CCEDA9

Q35836622-AAF568D9-9B7B-47E7-8724-248FF6FE5FB6

Q35836622-B3C9009B-D163-4A3F-A42C-6148DC49A586

P304

Q35836622-EFEBD7A5-5A84-45DA-945F-5E9E0A86BF5A

P31

Q35836622-7CD7A6AE-E8CF-4D3E-8DC9-763EFBE5E126

P356

Q35836622-BD8603DF-99A4-40D9-9EA8-6D184B8C6792

P407

Q35836622-80C20D70-AC2F-4636-8D27-B0FC771D34B4

P433

Q35836622-362C510A-25F3-4B26-A6A4-E9084FCE646D

P478

Q35836622-050CD0A4-629E-4A4F-A4CA-62E9D2210ABF

P577

Q35836622-4723339A-4CCB-4120-9383-98C27EF77DA7

P5875

Q35836622-EAE4ED69-B52D-4470-B196-9FD4580FA99B

P698

Q35836622-9BDC49F5-1E9A-47B7-91A9-873D547B6E48

P932

Q35836622-C5B9C434-3EEB-485B-AB8D-4C27812ED788

P356

P1433

Organic Letters

P1476

Iron(III)/NaBH4-mediated addit ...... ovel 20'-vinblastine analogues

@en

P2093

Dale L Boger

http://www.w3.org/2001/XMLSchema#string

Erick K Leggans

http://www.w3.org/2001/XMLSchema#string

Katharine K Duncan

http://www.w3.org/2001/XMLSchema#string

Timothy J Barker

http://www.w3.org/2001/XMLSchema#string

P2860

Novel aspects of natural and modified vinca alkaloids.

Asymmetric total synthesis of vindoline

Total synthesis and evaluation of a key series of C5-substituted vinblastine derivatives

Asymmetric total synthesis of vindorosine, vindoline, and key vinblastine analogues

Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.

10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids.

Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids.

Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine

Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues

The discovery of the vinca alkaloids--chemotherapeutic agents against cancer.

P304

1428-1431

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/OL300173V

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

14

http://www.w3.org/2001/XMLSchema#string

P577

2012-02-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221865341

http://www.w3.org/2001/XMLSchema#string

P698

22369097

http://www.w3.org/2001/XMLSchema#string

P932

3306530

http://www.w3.org/2001/XMLSchema#string