VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
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Vacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of DiseaseVPS35 regulates cell surface recycling and signaling of dopamine receptor D1Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in MacaqueQuantitative proteomic analysis of Parkin substrates in Drosophila neurons.VPS35, the Retromer Complex and Parkinson's Disease.VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeastVPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response.The second report of a new hypomyelinating disease due to a defect in the VPS11 gene discloses a massive lysosomal involvementThe Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.Endocytic membrane trafficking and neurodegenerative disease.A conserved retromer sorting motif is essential for mitochondrial DLP1 recycling by VPS35 in Parkinson's disease model.ɑ-Synuclein strains and the variable pathologies of synucleinopathies.Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axisα-Synuclein-carrying extracellular vesicles in Parkinson's disease: deadly transmitters.Defects in trafficking bridge Parkinson's disease pathology and genetics.Rabs, Membrane Dynamics, and Parkinson's Disease.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.The LRRK2-macroautophagy axis and its relevance to Parkinson's diseaseThe emerging role of retromer in neuroprotection.Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy.DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy.The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.Autophagy impairment in Parkinson's disease.The functional roles of retromer in Parkinson's disease.Convergent pathways in Parkinson's disease.Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits.VPS35 depletion does not impair presynaptic structure and function.The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking.The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases.Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease.
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P2860
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
description
2015 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2015
@ast
im Juli 2015 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2015/07/22)
@sk
vědecký článek publikovaný v roce 2015
@cs
wetenschappelijk artikel (gepubliceerd op 2015/07/22)
@nl
наукова стаття, опублікована в липні 2015
@uk
مقالة علمية (نشرت في 22-7-2015)
@ar
name
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@ast
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@en
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@nl
type
label
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@ast
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@en
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@nl
prefLabel
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@ast
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@en
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@nl
P2093
P2860
P921
P3181
P1476
VPS35 in Dopamine Neurons Is R ...... genesis of Parkinson's Disease
@en
P2093
Baisha Tang
Dong-Min Yin
Fu-Lei Tang
P2860
P304
10613-10628
P3181
P356
10.1523/JNEUROSCI.0042-15.2015
P407
P577
2015-07-01T00:00:00Z