PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
about
SGK1: The Dark Side of PI3K Signaling.Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Ras-ling with new therapeutic targets for metastasis.Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination.PI3K signaling in cancer: beyond AKT.AKT/PKB Signaling: Navigating the Network.The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.The emerging role of serum/glucocorticoid-regulated kinases in cancer.Targeting PDK1 for Chemosensitization of Cancer Cells.Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA.SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway.PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation.The PI3K Pathway in Human Disease.Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance.The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme.Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy.The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells.Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.PDK1-WNK1 signaling is affected by HBx and involved in the viability and metastasis of hepatic cells.Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells via mTOR activation through Akt-independent pathway.SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT.A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy.Triple-negative breast cancer and the potential for targeted therapy
P2860
Q30399129-B55D0993-1FF2-486E-ACED-E17759A48BB3Q33622342-5F0179C4-B0DE-48E7-83C7-13735BE93C07Q38805139-95E5A166-2131-4E84-B29E-E276C56D3DC5Q39175989-BE24589B-C3F2-4005-B87B-8CA77ACA973DQ39200710-19ECC4AD-8F6C-474C-AE51-9B5ACEF6EBCEQ39255027-BFEB1215-FC58-4415-B614-4E9ED04F4B81Q41497888-10989CAC-38C2-4EC4-B67C-DDE223E612B9Q41728566-FA39F350-B9AC-4E4C-9A87-803A12C433C7Q43276810-6C9F2BCC-B1BB-4EDF-A84F-4A6A6D4F3A8EQ44970152-9BBE63CC-B4D3-4A74-9954-498E32618B5CQ45731755-A653A6DC-8A7C-4247-8316-F7917FDA4016Q46095420-448BCCE9-E603-45AF-8095-3EEB6541F250Q46546002-A08564F6-7852-43DE-A66B-221D3ACD15EBQ47390421-77B236C7-BBD2-4BE0-A2C6-BE2E2582E3A4Q47621500-FE587821-03F6-4ACB-A2C8-AC92F7A854BCQ47861000-D006DB76-D688-4050-80CB-FCE61F1FEB0EQ48193235-6B4A7460-F0D0-4E1F-B023-A3B4F4A1D791Q48263188-872275F8-C0A7-4BA8-BA2F-A6135DF62065Q51116483-9243FD00-EB11-41F8-871F-4E03D3623321Q52643619-DF8B9B8A-D610-43DD-8462-B0F262388367Q52716291-798A39E0-D4D9-4D53-9803-8983E94BB314Q55054888-3847A062-4FCF-4AEA-85B0-3E4B8AF4E76EQ55487384-F7EAA0F6-7512-4780-8C70-7D761AE88A29Q57115890-0279702D-9CC7-49CF-88F5-9C22F8CB5E55
P2860
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
description
2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2016
@ast
im August 2016 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2016/08/08)
@sk
vědecký článek publikovaný v roce 2016
@cs
wetenschappelijk artikel (gepubliceerd op 2016/08/08)
@nl
наукова стаття, опублікована в серпні 2016
@uk
مقالة علمية (نشرت في 8-8-2016)
@ar
name
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@ast
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@en
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@nl
type
label
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@ast
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@en
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@nl
prefLabel
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@ast
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@en
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@nl
P2093
P2860
P3181
P1433
P1476
PDK1-SGK1 Signaling Sustains A ...... Resistance to PI3Kα Inhibition
@en
P2093
Chandra S Verma
Dario R Alessi
Eneda Toska
F Javier Carmona
Haley Ellis
José Baselga
Maura Dickler
Maurizio Scaltriti
Ruzica Bago
P2860
P304
P3181
P356
10.1016/J.CCELL.2016.06.004
P577
2016-07-21T00:00:00Z