REV1 and polymerase ζ facilitate homologous recombination repair
about
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksCoordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivoConditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenanceStructural Basis of Recruitment of DNA Polymerase by Interaction between REV1 and REV7 ProteinsStructural insights into the assembly of human translesion polymerase complexesNMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase ηThe transcription factor TFII-I promotes DNA translesion synthesis and genomic stabilityRole of PCNA and TLS polymerases in D-loop extension during homologous recombination in humansCompetition between replicative and translesion polymerases during homologous recombination repair in DrosophilaError-Prone Repair of DNA Double-Strand Breaks.Reconstitution of recombination-associated DNA synthesis with human proteins.REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζTranslesion polymerase genes polymorphisms and haplotypes influence survival of osteosarcoma patients.Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells.Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistanceWhole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress.The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents.DNA polymerase zeta is required for proliferation of normal mammalian cells.Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck.Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses.The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase δ, η, and ζ activities.Homologous recombination rescues ssDNA gaps generated by nucleotide excision repair and reduced translesion DNA synthesis in yeast G2 cells.DNA damage tolerance: a double-edged sword guarding the genomeEffects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1.A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.A missense mutation in Rev7 disrupts formation of Polζ, impairing mouse development and repair of genotoxic agent-induced DNA lesions.Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.Mouse models of DNA polymerases.REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.Translesion DNA synthesis and mutagenesis in eukaryotesREV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1.Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival.c-Myc-miR-29c-REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma.
P2860
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P2860
REV1 and polymerase ζ facilitate homologous recombination repair
description
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artikull shkencor
@sq
artículu científicu espublizáu en 2012
@ast
im Januar 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2012
@uk
مقالة علمية (نشرت عام 2012)
@ar
name
REV1 and polymerase ζ facilitate homologous recombination repair
@ast
REV1 and polymerase ζ facilitate homologous recombination repair
@en
REV1 and polymerase ζ facilitate homologous recombination repair
@nl
type
label
REV1 and polymerase ζ facilitate homologous recombination repair
@ast
REV1 and polymerase ζ facilitate homologous recombination repair
@en
REV1 and polymerase ζ facilitate homologous recombination repair
@nl
prefLabel
REV1 and polymerase ζ facilitate homologous recombination repair
@ast
REV1 and polymerase ζ facilitate homologous recombination repair
@en
REV1 and polymerase ζ facilitate homologous recombination repair
@nl
P2093
P2860
P3181
P356
P1476
REV1 and polymerase ζ facilitate homologous recombination repair
@en
P2093
Christine E. Canman
Colleen L. Chute
J. Kevin Hicks
Joon-Young Ahn
Julia R. Brennan
Shilpy Sharma
Thomas W. Glover
P2860
P304
P3181
P356
10.1093/NAR/GKR769
P407
P577
2012-01-01T00:00:00Z