Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation
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Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylationThe role of p21-activated kinases in hepatocellular carcinoma metastasisThe mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activityPAK as a therapeutic target in gastric cancerP21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformationShank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanismCdc42/Rac1-mediated activation primes PAK2 for superactivation by tyrosine phosphorylation.p21-activated kinase regulates endothelial permeability through modulation of contractility.Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1.Reciprocally coupled residues crucial for protein kinase Pak2 activity calculated by statistical coupling analysisGastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanismsCharacterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1.Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation.The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.PAK1 as a therapeutic target.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationDbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response.Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo.Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretionThe p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis eventsp21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.Quantitative phosphoproteomic analysis of the tumor necrosis factor pathwayA tale of two Paks.A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cellsRegulation of cardiac excitation and contraction by p21 activated kinase-1Pak protein kinases and their role in cancer.PAK signaling in oncogenesis.PAK signaling in cancer.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.Conformational switch and role of phosphorylation in PAK activationMechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification.Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.Localization of p21-activated protein kinase gamma-PAK/Pak2 in the endoplasmic reticulum is required for induction of cytostasis.Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused.Cdc42-independent activation and translocation of the cytostatic p21-activated protein kinase gamma-PAK by sphingosine.
P2860
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P2860
Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation
description
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im März 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/03/19)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/03/19)
@nl
наукова стаття, опублікована в березні 1999
@uk
name
Multisite autophosphorylation ...... AK as a function of activation
@ast
Multisite autophosphorylation ...... AK as a function of activation
@en
Multisite autophosphorylation ...... AK as a function of activation
@nl
type
label
Multisite autophosphorylation ...... AK as a function of activation
@ast
Multisite autophosphorylation ...... AK as a function of activation
@en
Multisite autophosphorylation ...... AK as a function of activation
@nl
prefLabel
Multisite autophosphorylation ...... AK as a function of activation
@ast
Multisite autophosphorylation ...... AK as a function of activation
@en
Multisite autophosphorylation ...... AK as a function of activation
@nl
P2093
P2860
P3181
P356
P1476
Multisite autophosphorylation ...... AK as a function of activation
@en
P2093
J. A. Traugh
P. T. Tuazon
P2860
P304
P3181
P356
10.1074/JBC.274.12.8022
P407
P577
1999-03-19T00:00:00Z