Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564
about
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.Demonstration that fbiC is required by Mycobacterium bovis BCG for coenzyme F(420) and FO biosynthesisRadical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methodsComparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathwaysStructural characterization of the mitomycin 7-O-methyltransferaseOrigin, distribution and 3D-modeling of Gr-EXPB1, an expansin from the potato cyst nematode Globodera rostochiensis.Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C.PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes.Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes.Carbamoylphosphate requirement for synthesis of the active center of [NiFe]-hydrogenases.Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpACharacterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.Biosynthetic studies of aziridine formation in azicemicins.Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system.Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCGLarge-scale production of coenzyme F420-5,6 by using Mycobacterium smegmatis.Biosynthesis of 3,5-AHBA-derived natural products.Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products.Involvement of a cytochrome P450 monooxygenase in thaxtomin A biosynthesis by Streptomyces acidiscabies.Regulation of the Streptomyces coelicolor calcium-dependent antibiotic by absA, encoding a cluster-linked two-component systemCYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces.A comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolismNatural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.Hot or not? Discovery and characterization of a thermostable alditol oxidase from Acidothermus cellulolyticus 11B.Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches.iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions.The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.GPE Promotes the Proliferation and Migration of Mouse Embryonic Neural Stem Cells and Their Progeny In Vitro.Actinobacteria and Myxobacteria-Two of the Most Important Bacterial Resources for Novel Antibiotics.Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent.Cloning of a genetically unstable cytochrome P-450 gene cluster involved in degradation of the pollutant ethyl tert-butyl ether by Rhodococcus ruber.Fum3p, a 2-ketoglutarate-dependent dioxygenase required for C-5 hydroxylation of fumonisins in Fusarium verticillioides.Metabolic tinker: an online tool for guiding the design of synthetic metabolic pathways.
P2860
Q24534370-D3074088-8EC1-46A8-80B0-0DD2C8CC2D3BQ24538944-7B916F26-CBBF-4C42-9FE7-CAB5429E1182Q24616026-41B719C3-DDFC-4C9E-9932-B5F5D804ABEEQ27642846-4E01DABC-6FC1-4AE9-A32D-EC436FE19328Q27667659-620BB5E9-0A1E-4425-8302-CEBD918321FBQ30160260-DDFB71BD-BDC6-4C94-8EFE-43F79CC2AEC2Q30486171-8A2AC617-A818-4612-A3C3-AA1187659AD6Q30617805-78F4136F-085C-4164-879D-EBE554263222Q30779887-9912277C-BD36-4426-B962-0264944BEEBFQ31864425-897F0D80-F3DE-4D78-9AF0-C0233D87A10EQ32035273-9BCE6D1A-91D6-43EC-A9A7-0235826D66B7Q33304966-15346947-9F49-46E3-9D66-24C5601D1616Q33552290-159FEAB7-0999-4ABC-9663-DCC1BA5905ADQ33858324-F55D3250-8CC7-4568-B76A-F267EB019588Q33913477-D1FAAAA5-5FE1-4ED6-A1D3-F08B68E1524CQ33997178-CF2643E2-CD23-44C9-ABBD-C07E29619827Q34165572-631F74D6-F83E-4236-8F54-ADF51730B039Q34242480-0CF74E2D-EE55-47D7-B9A9-9BCC9169D596Q34284718-4702D98A-6DD8-4B0B-8370-AC6032E91056Q34307387-1880DCC6-0987-429A-9FB4-905CF44C8FA2Q34434245-4767DDC7-7E89-4ED4-BF12-4669D45B37D3Q34442348-007BF294-E0F0-4F8F-B2B8-D992FACE474CQ35081384-BA8B6F17-4D3F-4D06-A13A-F6CD53BDB8C1Q35215703-8C61AF28-6434-4274-BFDA-BCF677D6375BQ35662238-645408B4-FD90-466B-AB20-8A34B2CF0102Q35785144-E7B9B4E5-B2A6-4857-9AA4-8E11B2A86D28Q36020062-CD76CBD3-639A-4503-A9FF-CABFA4683E4EQ36120027-6D274160-60A7-43B1-B236-F053607C874EQ36435230-23E4A0FF-DA20-42F2-A52E-526A159D9867Q37396793-54BF8E4A-D154-419F-AC6B-ABD10A3C3FBEQ37447788-9D9E9321-72CC-427F-9301-0AE3DA56C8DBQ37595686-70A82A0F-D925-4D43-825F-A972ADE4AE1BQ37809968-89571B57-66AA-485B-A4B9-0CDDD2144ADCQ37845949-FF0CEA29-D925-4E6F-ABB4-6CEB058568E5Q38722527-8694D678-B776-4B11-8A84-0091E9E56376Q38814785-0A730C13-A4E9-4A8A-BC5C-57BD855F76FCQ39011105-F96F81FB-0859-4B14-96EB-DB5E6A78226CQ39505164-4277A2DF-BCA6-456E-8B83-C5BA283FFA70Q40743925-134D8576-A4BF-4286-BFB2-F82F97589714Q41767208-EEF1D9C5-FC59-435B-A682-28D0A28F2031
P2860
Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@ast
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@en
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@nl
type
label
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@ast
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@en
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@nl
prefLabel
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@ast
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@en
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@nl
P2093
P921
P1476
Molecular characterization and ...... eptomyces lavendulae NRRL 2564
@en
P2093
P304
P356
10.1016/S1074-5521(99)80040-4
P407
P577
1999-04-01T00:00:00Z