Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL - Test2 - elhamkhani - TriplyDB

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

http://www.wikidata.org/entity/Q28141139

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Function, regulation and pathological roles of the Gab/DOS docking proteins Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2 T cell regulation of p62(dok) (Dok1) association with Crk-L Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology An overview of the c-MET signaling pathway Essential role of Gab1 for signaling by the c-Met receptor in vivo Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton Normal morphogenesis of epithelial tissues and progression of epithelial tumors.Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions Met receptor tyrosine kinase: enhanced signaling through adapter proteins GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2 A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses The small GTPase Rap1 promotes cell movement rather than stabilizes adhesion in epithelial cells responding to insulin-like growth factor I.Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.C3G-mediated suppression of oncogene-induced focus formation in fibroblasts involves inhibition of ERK activation, cyclin A expression and alterations of anchorage-independent growth.Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review.Control of cell adhesion dynamics by Rap1 signaling.The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor.Self-organization and regulation of intrinsically disordered proteins with folded N-termini.Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras.Activation and function of the Rap1 GTPase in B lymphocytes.Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells.The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Anxiety Increases After Zinc Therapy.E-cadherin dis-engagement activates the Rap1 GTPase.

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Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

http://www.wikidata.org/entity/Q28141139

description

2000 nî lūn-bûn

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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի ապրիլին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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type

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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Journal of Biological Chemistry

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Signaling of hepatocyte growth ...... 1 and the adapter protein CRKL

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D Sakkab

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P2860

The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration.

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.

Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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