Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine - Test2 - elhamkhani - TriplyDB

Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

http://www.wikidata.org/entity/Q28141684

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Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA)Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA)Dual dopamine/serotonin releasers: potential treatment agents for stimulant addiction Serotonergic drugs and valvular heart disease Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions Pharmacological targeting of the serotonergic system for the treatment of obesity Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus Structure and function of serotonin G protein-coupled receptors.Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors.The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals.Predictive in silico studies of human 5-hydroxytryptamine receptor subtype 2B (5-HT2B) and valvular heart disease Safety of antiobesity drugs.Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole.Serotonin regulates pancreatic beta cell mass during pregnancy.Serotonin receptors and heart valve disease--it was meant 2B.Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors.Recent advances in clinical practice challenges and opportunities in the management of obesity.Potential drug targets for calcific aortic valve disease.Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.The expanded biology of serotonin.Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues.Aortic valve cyclic stretch causes increased remodeling activity and enhanced serotonin receptor responsiveness Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control In silico pharmacology for drug discovery: applications to targets and beyond Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.Serotonin and the regulation of mammalian energy balance.Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.Effect of (-)-trans-PAT, a novel 5-HT2C receptor agonist, on intake of palatable food in mice.Molecular Determinants for Ligand Binding at Serotonin 5-HT2A and 5-HT2C GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies Lorcaserin for the treatment of obesity Role of serotoninergic pathways in drug-induced valvular heart disease and diagnostic features by echocardiography Appetite suppressants, cardiac valve disease and combination pharmacotherapy Fenfluramine disrupts the mitral valve interstitial cell response to serotonin.

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P2860

Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

http://www.wikidata.org/entity/Q28141684

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2000 nî lūn-bûn

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2000年の論文

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Possible role of valvular sero ...... y associated with fenfluramine

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