Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma - Test2 - elhamkhani - TriplyDB

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

http://www.wikidata.org/entity/Q28141888

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The Gordon Wilson Lecture: The clinical legacy of Jonathan Hutchinson (1828-1913): syndromology and dysmorphology meet genomics Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4)A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics.No association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population.Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome Germline mutations of the STK11 gene in Korean Peutz-Jeghers syndrome patients.Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma LKB1, a protein kinase regulating cell proliferation and polarity.STRAD in Peutz-Jeghers syndrome and sporadic cancers.LKB1 preserves genome integrity by stimulating BRCA1 expression.The LKB1 tumor suppressor as a biomarker in mouse and human tissues.5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer.NUAK2: an emerging acral melanoma oncogene Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers.Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1.LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment Prevalence and specificity of LKB1 genetic alterations in lung cancers Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer.LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4 Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.LKB1; linking cell structure and tumor suppression.Dysregulation of mTOR activity through LKB1 inactivation.PI3K/Akt/mTOR signaling & its regulator tumour suppressor genes PTEN & LKB1 in human uterine leiomyomas.Rewiring cell polarity signaling in cancer.LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated.LKB1/AMPK pathway mediates resistin-induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes.Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma GSK-3beta directly phosphorylates and activates MARK2/PAR-1.Prognostic significance of LKB1 promoter methylation in cutaneous malignant melanoma Energizing the search to target LKB1-mutant tumors.

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

http://www.wikidata.org/entity/Q28141888

description

1999 nî lūn-bûn

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1999年論文

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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A F Kirkin

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J Zeuthen

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P Guldberg

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P thor Straten

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T Seremet

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V Ahrenkiel

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AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

A cell cycle regulator potentially involved in genesis of many tumor types

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Increased risk of cancer in the Peutz-Jeghers syndrome.

Molecular mechanisms controlling human melanoma progression and metastasis.

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10.1038/SJ.ONC.1202486

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1016492922

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10208439

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