A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome - Test2 - elhamkhani - TriplyDB

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

http://www.wikidata.org/entity/Q28307804

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Repurposing metformin: an old drug with new tricks in its binding pockets A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation Paraneoplastic dermatological manifestation of gastrointestinal malignancies Targeting LKB1 in cancer - exposing and exploiting vulnerabilities Diverse mechanisms of AKT pathway activation in human malignancy AMPK: a cellular metabolic and redox sensor. A minireview Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms?TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.Regulation of LKB1/STRAD localization and function by E-cadherin.Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer Enhancing mTOR-targeted cancer therapy.A gene-alteration profile of human lung cancer cell lines.Lung cancer cell lines as tools for biomedical discovery and research LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53.The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.Epidemiology of cancer of the small intestine Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers LKB1 reduces ROS-mediated cell damage via activation of p38.Metabolic alterations and targeted therapies in prostate cancer.CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts.Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase.LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects.The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.Role of LKB1 in lung cancer development.Impact of genetic alterations on mTOR-targeted cancer therapy

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A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

http://www.wikidata.org/entity/Q28307804

description

2007 nî lūn-bûn

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2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

@ast

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

@en

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

@nl

type

label

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

@ast

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

@en

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

@nl

prefLabel

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

@ast

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

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A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

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A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity

Mutation and cancer: statistical study of retinoblastoma

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

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10.1038/SJ.ONC.1210594

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26

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1043546902

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17599048

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