A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
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PPARG binding landscapes in macrophages suggest a genome-wide contribution of PU.1 to divergent PPARG binding in human and mouseLiver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDLInflammation, stress, and diabetesSynthetic LXR ligand inhibits the development of atherosclerosis in miceThe peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domainA selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transportApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse modelsPPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1PPARs and the cardiovascular systemAbsence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/IICD36: implications in cardiovascular diseaseOrphan nuclear receptors and the regulation of nutrient metabolism: understanding obesityEmerging role of mast cells and macrophages in cardiovascular and metabolic diseasesPPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertaintyOpportunities for the treatment of inflammation in cardiovascular diseaseNo genetic association between ATP binding cassette proteins and Japanese sporadic Alzheimer's diseaseThe role of fatty acid binding proteins in metabolic syndrome and atherosclerosisApolipoprotein E and Alzheimer disease: risk, mechanisms and therapyGPR109A and vascular inflammationThree-dimensional micro computed tomography analysis of the lung vasculature and differential adipose proteomics in the Sugen/hypoxia rat model of pulmonary arterial hypertensionHost defense against viral infection involves interferon mediated down-regulation of sterol biosynthesisAn innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatmentThe fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activitiesThe farnesoid X-receptor is an essential regulator of cholesterol homeostasisLiver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesisTranscription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cellsEffects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer.Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in ratsSmooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.Are thiazolidinediones good or bad for the heart?12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models.Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice.Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells.Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism.A concerted kinase interplay identifies PPARgamma as a molecular target of ghrelin signaling in macrophages.Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice.Thiazolidinedione-independent activation of peroxisome proliferator-activated receptor γ is a potential target for diabetic macrovascular complications.
P2860
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P2860
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@ast
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@en
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@nl
type
label
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@ast
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@en
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@nl
prefLabel
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@ast
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@en
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@nl
P2093
P3181
P1433
P1476
A PPAR gamma-LXR-ABCA1 pathway ...... terol efflux and atherogenesis
@en
P2093
B A Laffitte
L K Curtiss
P A Edwards
P Tontonoz
W A Boisvert
P304
P3181
P356
10.1016/S1097-2765(01)00164-2
P407
P577
2001-01-01T00:00:00Z