Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia - Test2 - elhamkhani - TriplyDB

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia

http://www.wikidata.org/entity/Q28204028

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The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2 Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development Adaptor protein ARH is recruited to the plasma membrane by low density lipoprotein (LDL) binding and modulates endocytosis of the LDL/LDL receptor complex in hepatocytes The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9 CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors.The thyromimetic T-0681 protects from atherosclerosis.The endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis.Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis.The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake.Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation Giardia lamblia low-density lipoprotein receptor-related protein is involved in selective lipoprotein endocytosis and parasite replication.Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.Quantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake.S-nitrosylation of ARH is required for LDL uptake by the LDL receptor.Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney.Identification of novel and known oocyte-specific genes using complementary DNA subtraction and microarray analysis in three different species.Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.Internalized PCSK9 dissociates from recycling LDL receptors in PCSK9-resistant SV-589 fibroblasts Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB.The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits.Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.Xenopus autosomal recessive hypercholesterolemia protein couples lipoprotein receptors with the AP-2 complex in oocytes and embryos and is required for vitellogenesis.

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P2860

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia

http://www.wikidata.org/entity/Q28204028

description

2003 nî lūn-bûn

@nan

2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Normal sorting but defective e ...... recessive hypercholesterolemia

@ast

Normal sorting but defective e ...... recessive hypercholesterolemia

@en

Normal sorting but defective e ...... recessive hypercholesterolemia

@nl

type

label

Normal sorting but defective e ...... recessive hypercholesterolemia

@ast

Normal sorting but defective e ...... recessive hypercholesterolemia

@en

Normal sorting but defective e ...... recessive hypercholesterolemia

@nl

prefLabel

Normal sorting but defective e ...... recessive hypercholesterolemia

@ast

Normal sorting but defective e ...... recessive hypercholesterolemia

@en

Normal sorting but defective e ...... recessive hypercholesterolemia

@nl

P1433

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P356

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Journal of Biological Chemistry

P1476

Normal sorting but defective e ...... recessive hypercholesterolemia

@en

P2093

Christopher Jones

http://www.w3.org/2001/XMLSchema#string

Helen H Hobbs

http://www.w3.org/2001/XMLSchema#string

Joachim Herz

http://www.w3.org/2001/XMLSchema#string

Jonathan C Cohen

http://www.w3.org/2001/XMLSchema#string

Robert E Hammer

http://www.w3.org/2001/XMLSchema#string

Wei-Ping Li

http://www.w3.org/2001/XMLSchema#string

P2860

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor

ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

Molecular mechanisms of autosomal recessive hypercholesterolemia

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

P304

29024-30

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scholarly article

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10.1074/JBC.M304855200

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P433

31

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278

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2003-08-01T00:00:00Z

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12746448

http://www.w3.org/2001/XMLSchema#string

P921

Low density lipoprotein receptor

Early endosome antigen 1

Low density lipoprotein receptor adaptor protein 1

autosomal recessive hypercholesterolemia

hypercholesterolemia