Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
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The subsystems approach to genome annotation and its use in the project to annotate 1000 genomesStructure of the Type III Pantothenate Kinase from Bacillus anthracis at 2.0 Å Resolution: Implications for Coenzyme A-Dependent Redox Biology † , ‡Structural and Functional Studies of Aspergillus clavatus N 5 -Carboxyaminoimidazole Ribonucleotide Synthetase,Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureusCharacterization of a new pantothenate kinase isoform from Helicobacter pyloriCrystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteriaIdentification of gene targets against dormant phase Mycobacterium tuberculosis infectionsPantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus.Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activityChallenges of antibacterial discoveryIdentification of group A Streptococcus antigenic determinants upregulated in vivo.Changes in the Staphylococcus aureus transcriptome during early adaptation to the lung.Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivatedGeminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity.Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferaseThe antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis.New advances in antibiotic development and discovery.A cross-metathesis approach to novel pantothenamide derivatives.Biosynthesis of Pantothenic Acid and Coenzyme A.Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activityExploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections.Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.Antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type II pantothenate kinase.Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa.Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.4'-phosphopantetheine and coenzyme A biosynthesis in plants.Active-site residues and amino acid specificity of the bacterial 4'-phosphopantothenoylcysteine synthetase CoaB.A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.Role of prokaryotic type I and III pantothenate kinases in the coenzyme A biosynthetic pathway of Bacillus subtilis.
P2860
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P2860
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@ast
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@en
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@nl
type
label
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@ast
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@en
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@nl
prefLabel
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@ast
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@en
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@nl
P2093
P2860
P1476
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
@en
P2093
Anthony E Choudhry
Cynthia Kinsland
James R Brown
John P Broskey
Kapila Ratnam
Magdalena Zalacain
Mark A Seefeld
Richard W Egolf
Tadhg P Begley
Thomas W Ku
P2860
P304
P356
10.1128/AAC.47.6.2051-2055.2003
P407
P577
2003-06-01T00:00:00Z