Biomimetic synthesis and optimization of cyclic peptide antibiotics
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"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptidesReaction discovery enabled by DNA-templated synthesis and in vitro selectionNew antibiotics--resistance is futileStructural and Biochemical Characterization of Linear Dinucleotide Analogues Bound to the c-di-GMP-I AptamerThe high resolution structure of tyrocidine A reveals an amphipathic dimerHeterologous expression and structural characterisation of a pyrazinone natural product assembly lineRing-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.High-throughput synthesis and screening of cyclic peptide antibiotics.Method for screening and MALDI-TOF MS sequencing of encoded combinatorial libraries.Synthesis and screening of a cyclic peptide library: discovery of small-molecule ligands against human prolactin receptorTranslation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection.Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.Cyclic peptides as therapeutic agents and biochemical tools.Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analoguesNonribosomal peptide synthetases involved in the production of medically relevant natural products.Enzyme-catalyzed macrocyclization of long unprotected peptides.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides.Discovery of MRSA active antibiotics using primary sequence from the human microbiome.Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.Nonribosomal Peptide Synthesis-Principles and Prospects.Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptidesCyclization of fungal nonribosomal peptides by a terminal condensation-like domainActivity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometryThioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.Development of Tyrocidine A analogues with improved antibacterial activity.PKS and NRPS release mechanisms.Frontiers and opportunities in chemoenzymatic synthesis.Contemporary strategies for peptide macrocyclization.Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?Synthetic Strategy and Anti-Tumor Activities of Macrocyclic Scaffolds Based on 4-Hydroxyproline.Cell-permeable bicyclic peptide inhibitors against intracellular proteins.Macrocycles: lessons from the distant past, recent developments, and future directions.Ring-Expansion Reactions in the Synthesis of Macrocycles and Medium-Sized Rings.Metabolic engineering--a genetic toolbox for small molecule organic synthesis.Synthesis and antibacterial activities of novel tyrocidine A glycosylated derivatives towards multidrug-resistant pathogens.A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.Massetolide A biosynthesis in Pseudomonas fluorescens.Peptide bicycles that inhibit the Grb2 SH2 domain.
P2860
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P2860
Biomimetic synthesis and optimization of cyclic peptide antibiotics
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@ast
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@en
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@nl
type
label
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@ast
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@en
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@nl
prefLabel
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@ast
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@en
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@nl
P2860
P356
P1433
P1476
Biomimetic synthesis and optimization of cyclic peptide antibiotics
@en
P2093
Christopher T Walsh
Michael D Burkart
P2860
P2888
P304
P356
10.1038/NATURE00907
P407
P577
2002-08-08T00:00:00Z
P6179
1014229180