"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides
about
Biological synthesis of circular polypeptidesBiosynthesis and biological screening of a genetically encoded library based on the cyclotide MCoTI-I.Cyclotides, a promising molecular scaffold for peptide-based therapeutics.Intein applications: from protein purification and labeling to metabolic control methods.Backbone dynamics of cyclotide MCoTI-I free and complexed with trypsin.Recent progress in intein research: from mechanism to directed evolution and applications.Peptide aptamers: development and applications.Recombinant expression of backbone-cyclized polypeptides.Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy.Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensinsHost-defense activities of cyclotides.Biological activities of natural and engineered cyclotides, a novel molecular scaffold for peptide-based therapeutics.Cyclotides, a novel ultrastable polypeptide scaffold for drug discoveryEfficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing.Chemical and biological production of cyclotides.The two-step biosynthesis of cyclic peptides from linear precursors in a member of the plant family Caryophyllaceae involves cyclization by a serine protease-like enzymeExpression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions.Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis.Inteins, valuable genetic elements in molecular biology and biotechnology.Cyclotides: a patent review.Patchwork protein chemistry: a practitioner's treatise on the advances in synthetic peptide stitchery.Cyclotides as grafting frameworks for protein engineering and drug design applications.Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways.Peptide bicycles that inhibit the Grb2 SH2 domain.In-cell production of a genetically-encoded library based on the θ-defensin RTD-1 using a bacterial expression system.Recombinant Expression of Cyclotides Using Split Inteins.Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation.
P2860
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P2860
"Splicing up" drug discovery. Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@ast
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@en
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@nl
type
label
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@ast
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@en
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@nl
prefLabel
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@ast
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@en
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@nl
P2860
P1476
"Splicing up" drug discovery. ...... backbone-cyclized polypeptides
@en
P2093
Julio A Camarero
P2860
P304
P356
10.1016/J.ADDR.2009.07.003
P407
P577
2009-09-30T00:00:00Z