CDK8 is a stimulus-specific positive coregulator of p53 target genes - Test2 - elhamkhani - TriplyDB

CDK8 is a stimulus-specific positive coregulator of p53 target genes

CDK8 is a stimulus-specific positive coregulator of p53 target genes

http://www.wikidata.org/entity/Q28235350

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A toxicology suite adapted for comparing parallel toxicity responses of model human lung cells to diesel exhaust particles and their extracts HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia Human mediator subunit MED26 functions as a docking site for transcription elongation factors Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants Mediator kinase module and human tumorigenesis Structure-kinetic relationship study of CDK8/CycC specific compounds Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae.Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16 Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.The p53 circuit board MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8 The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans The human Mediator complex: a versatile, genome-wide regulator of transcription A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.The Mediator complex and transcription regulation A cardiac microRNA governs systemic energy homeostasis by regulation of MED13 INMAP overexpression inhibits cell proliferation, induces genomic instability and functions through p53/p21 pathways The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha Tumor-suppressive effects of CDK8 in endometrial cancer cells.Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts.Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis.Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas.Regulation of the p53 transcriptional response by structurally diverse core promoters.Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.The menin tumor suppressor protein is phosphorylated in response to DNA damage A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.Mechanisms of regulatory diversity within the p53 transcriptional network.Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation CDK8 is a positive regulator of transcriptional elongation within the serum response network.The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8.

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P2860

CDK8 is a stimulus-specific positive coregulator of p53 target genes

http://www.wikidata.org/entity/Q28235350

description

2007 nî lūn-bûn

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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2007 թվականի հուլիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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J.MOLCEL.2007.05.026

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CDK8 is a stimulus-specific positive coregulator of p53 target genes

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Aaron Joseph Donner

http://www.w3.org/2001/XMLSchema#string

Jennifer Michelle Hoover

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Joaquin Maximiliano Espinosa

http://www.w3.org/2001/XMLSchema#string

Stephanie Szostek

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P2860

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12.

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase.

Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.

Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.

A high resolution protein interaction map of the yeast Mediator complex.

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17612495

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