Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease - Test2 - elhamkhani - TriplyDB

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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DNA Damage: A Main Determinant of Vascular Aging Photosensitive human syndromes Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae Diseases associated with defective responses to DNA damage DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency Systemic DNA damage responses in aging and diseases Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model.Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence.Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.Endogenous formation and repair of oxidatively induced G[8-5 m]T intrastrand cross-link lesion.Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).A Review of ERCC1 Gene in Bladder Cancer: Implications for Carcinogenesis and Resistance to Chemoradiotherapy The ERCC1 and ERCC4 (XPF) genes and gene products Comparison of mice with accelerated aging caused by distinct mechanisms Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice Can a young muscle's stem cell secretome prolong our lives?The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition.Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia.The expression of ERCC1 and BRCA1 predicts prognosis of platinum-based chemotherapy in urothelial cancer.DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals.Association between XRCC1 and ERCC1 single-nucleotide polymorphisms and the efficacy of concurrent radiochemotherapy in patients with esophageal squamous cell carcinoma.Xeroderma pigmentosum-Cockayne syndrome complex.Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems.mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging XPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF.Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinoma.

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

http://www.wikidata.org/entity/Q28238547

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2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年论文

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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J.DNAREP.2011.04.026

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Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease

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Andria Rasile Robinson

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Laura J Niedernhofer

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Siobhán Q Gregg

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Delayed and accelerated aging share common longevity assurance mechanisms

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

Mapping of interaction domains between human repair proteins ERCC1 and XPF

Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

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