Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID
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Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiencyCloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cellsIdentification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptorInterleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor geneFunctional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylationMissense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiencyDifferent interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferationIL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiationFunctional cleavage of the common cytokine receptor gamma chain (gammac) by calpainTwo mutational hotspots in the interleukin-2 receptor gamma chain gene causing human X-linked severe combined immunodeficiencyThe molecular pathology of primary immunodeficienciesJanus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Inborn errors of the development of human natural killer cellsHierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activationCharacterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activationDistinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signalingCytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complexMutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE reviewExpression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cellsInterleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinasesA kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cellsInterleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cellsInterleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytesp70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytesJak3 negatively regulates dendritic-cell cytokine production and survivalDistinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversityMolecular characterization of an alpha interferon receptor 1 subunit (IFNaR1) domain required for TYK2 binding and signal transductionTyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signalingPyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathwayHeteromerization of the c Chain with the Interleukin-9 Receptor Subunit Leads to STAT Activation and Prevention of ApoptosisSevere combined immunodeficiencies (SCID)Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor.Interleukin-4 Expressed By Neoplastic Cells Provokes an Anti-Metastatic Myeloid Immune Response.IL-2 independent transformation of a unique human T cell line, TY8-3, and its subclones by HTLV-I and -II.JAK and MPL mutations in myeloid malignancies.The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes
P2860
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P2860
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID
description
1994 nî lūn-bûn
@nan
1994 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@ast
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@en
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@nl
type
label
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@ast
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@en
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@nl
prefLabel
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@ast
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@en
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@nl
P2093
P3181
P356
P1433
P1476
Interaction of IL-2R beta and ...... mplications for XSCID and XCID
@en
P2093
B A Witthuhn
D W McVicar
J A Johnston
M Friedmann
M Kawamura
O Silvennoinen
S M Russell
P304
P3181
P356
10.1126/SCIENCE.7973658
P407
P577
1994-11-11T00:00:00Z