Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity
about
Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cellsDistinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activityA low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells.The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.Detection of a functional hybrid receptor gammac/GM-CSFRbeta in human hematopoietic CD34+ cells.Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail.Interleukin-2 receptor signaling in regulatory T cell development and homeostasisHuman immunodeficiency virus type 1 infection inhibits granulocyte-macrophage colony-stimulating factor-induced activation of STAT5A in human monocyte-derived macrophages.Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.Biochemical analysis of interleukin-2 receptor beta chain phosphorylation by p56(lck).A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor.Different tyrosine autophosphorylation requirements in fibroblast growth factor receptor-1 mediate urokinase-type plasminogen activator induction and mitogenesis.Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogrammingAnti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit.Carbohydrate recognition site of interleukin-2 in relation to cell proliferation.Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machineryConstitutive association of JAK1 and STAT5 in pro-B cells is dissolved by interleukin-4-induced tyrosine phosphorylation of both proteins.The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain.Prolactin receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways.An interleukin (IL)-13 receptor lacking the cytoplasmic domain fails to transduce IL-13-induced signals and inhibits responses to IL-4.Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes.Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling.Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17.Phosphorylation of IL2RB Y338; Y392 or Y510 enables STAT recruitmentp-STAT5 dimerizesTRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling.
P2860
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P2860
Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity
description
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im August 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/08/30)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/08/30)
@nl
наукова стаття, опублікована в серпні 1996
@uk
name
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@ast
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@en
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@nl
type
label
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@ast
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@en
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@nl
prefLabel
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@ast
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@en
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@nl
P2093
P2860
P356
P1476
Distinct tyrosine residues wit ...... ity, redundancy, and diversity
@en
P2093
P2860
P304
21381-21390
P356
10.1074/JBC.271.35.21381
P407
P577
1996-08-01T00:00:00Z