Unraveling the mechanism of BRCA2 in homologous recombination - Test2 - elhamkhani - TriplyDB

Unraveling the mechanism of BRCA2 in homologous recombination

Unraveling the mechanism of BRCA2 in homologous recombination

http://www.wikidata.org/entity/Q28242443

about

The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response Sources of DNA double-strand breaks and models of recombinational DNA repair Microbial antigenic variation mediated by homologous DNA recombination Single-stranded DNA-binding proteins: multiple domains for multiple functions Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination From yeast to mammals: recent advances in genetic control of homologous recombination Genetic evidence suggests that Spata22 is required for the maintenance of Rad51 foci in mammalian meiosis MEIOB targets single-strand DNA and is necessary for meiotic recombination Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Pseudosynapsis and decreased stringency of meiotic repair pathway choice on the hemizygous sex chromosome of Caenorhabditis elegans males Rapid evolution of BRCA1 and BRCA2 in humans and other primates.TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer.Rad51 regulates cell cycle progression by preserving G2/M transition in mouse embryonic stem cells.Preimplantation genetic diagnosis using combined strategies on a breast cancer patient with a novel genomic deletion in BRCA2.Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.Targeting the homologous recombination pathway by small molecule modulators Brca2 deficiency leads to T cell loss and immune dysfunction.Dual DNA-binding domains shape the interaction of Brh2 with DNA.Rescue of replication failure by Fanconi anaemia proteins.Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure LAMMER kinase contributes to genome stability in Ustilago maydis.Homologous recombination and its regulation Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.Architectural plasticity of human BRCA2-RAD51 complexes in DNA break repair.Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity.Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma.Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined "Complementary Lethality".

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P2860

Unraveling the mechanism of BRCA2 in homologous recombination

http://www.wikidata.org/entity/Q28242443

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Unraveling the mechanism of BRCA2 in homologous recombination

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Unraveling the mechanism of BRCA2 in homologous recombination

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Unraveling the mechanism of BRCA2 in homologous recombination

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type

label

Unraveling the mechanism of BRCA2 in homologous recombination

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Unraveling the mechanism of BRCA2 in homologous recombination

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Unraveling the mechanism of BRCA2 in homologous recombination

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prefLabel

Unraveling the mechanism of BRCA2 in homologous recombination

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Unraveling the mechanism of BRCA2 in homologous recombination

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Unraveling the mechanism of BRCA2 in homologous recombination

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Nature Structural & Molecular Biology

P1476

Unraveling the mechanism of BRCA2 in homologous recombination

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P2093

William K Holloman

http://www.w3.org/2001/XMLSchema#string

P2860

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control

Purified human BRCA2 stimulates RAD51-mediated recombination

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1

Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51

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748-54

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scholarly article

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3515054

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10.1038/NSMB.2096

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7

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18

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2011-07-06T00:00:00Z

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51469113

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21731065

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structural biology

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3647347

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