Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication - Test2 - elhamkhani - TriplyDB

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

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Mutational landscape of aggressive cutaneous squamous cell carcinoma Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers Eukaryotic genome instability in light of asymmetric DNA replication A panoply of errors: polymerase proofreading domain mutations in cancer Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity A Simple Model-Based Approach to Inferring and Visualizing Cancer Mutation Signatures.Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant Rational design of non-resistant targeted cancer therapies Limited impact of intratumour heterogeneity on molecular risk assignment in endometrial cancer.Rapid evolution of the human mutation spectrum Eukaryotic Mismatch Repair in Relation to DNA Replication Processing ribonucleotides incorporated during eukaryotic DNA replication.Comparison of the kinetic parameters of the truncated catalytic subunit and holoenzyme of human DNA polymerase ɛ.Volatility of Mutator Phenotypes at Single Cell Resolution Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae.Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair.Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ A novel germline POLE mutation causes an early onset cancer prone syndrome mimicking constitutional mismatch repair deficiency.Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibition.Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes.Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand.The role of neoantigens in response to immune checkpoint blockade.DNA Polymerases Divide the Labor of Genome Replication.Cancer predisposition syndromes: lessons for truly precision medicine.Eukaryotic DNA Replication Fork.Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Polymerase ζ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures.Yeast DNA polymerase ϵ catalytic core and holoenzyme have comparable catalytic rates POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups.Comprehensive Analysis of Hypermutation in Human Cancer.

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P2860

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

http://www.wikidata.org/entity/Q28248149

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2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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Exonuclease mutations in DNA p ...... d human origins of replication

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David A Wheeler

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Donna M Muzny

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Erin E Henninger

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Eve Shinbrot

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HarshaVardhan Doddapaneni

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Hsu Chao

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Kyle R Covington

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Nils Weinhold

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Richard A Gibbs

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P2860

The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Comprehensive molecular characterization of human colon and rectal cancer

Yeast DNA polymerase epsilon participates in leading-strand DNA replication

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

Unique error signature of the four-subunit yeast DNA polymerase epsilon.

The 3' 5' exonucleases

DNA polymerase proofreading: Multiple roles maintain genome stability

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1740-50

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scholarly article

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822895

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10.1101/GR.174789.114

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11

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24

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Zachary Pursell

Nikolaus Schultz

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2014-11-01T00:00:00Z

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265733211

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4216916

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