The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability
about
The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conservedActivation of an alternative, rec12 (spo11)-independent pathway of fission yeast meiotic recombination in the absence of a DNA flap endonucleaseIdling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replicationDNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombinationThe fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesOkazaki fragment maturation: nucleases take centre stagePolymerase dynamics at the eukaryotic DNA replication forkEnzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2Enzymatic processing of replication and recombination intermediates by the vaccinia virus DNA polymeraseA network of multi-tasking proteins at the DNA replication fork preserves genome stabilityDNA polymerase ε and its roles in genome stabilityDNA polymerase delta in DNA replication and genome maintenanceAntimutator variants of DNA polymerasesThe multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domainsStructure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.The quaternary structure of DNA polymerase epsilon from Saccharomyces cerevisiae.Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation.Reconstituted Okazaki fragment processing indicates two pathways of primer removal.Reconstitution of human DNA polymerase delta using recombinant baculoviruses: the p12 subunit potentiates DNA polymerizing activity of the four-subunit enzymeOkazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nickSensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae.Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replicationDNA polymerases at the eukaryotic fork-20 years laterReplicative DNA polymerase δ but not ε proofreads errors in Cis and in TransDivision of labor at the eukaryotic replication forkDNA polymerase ε and δ exonuclease domain mutations in endometrial cancerDNA replication fidelity and cancerSubtle alterations in PCNA-partner interactions severely impair DNA replication and repairA reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stabilityRPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta.The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal.FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells.Processing of lagging-strand intermediates in vitro by herpes simplex virus type 1 DNA polymeraseMutator suppression and escape from replication error-induced extinction in yeastHaploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progressionComputational protein design suggests that human PCNA-partner interactions are not optimized for affinity.Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease.Kinetic approaches to understanding the mechanisms of fidelity of the herpes simplex virus type 1 DNA polymerase
P2860
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P2860
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability
description
2001 nî lūn-bûn
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2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
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2001年論文
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2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
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2001年论文
@wuu
name
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@ast
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@en
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@nl
type
label
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@ast
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@en
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@nl
prefLabel
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@ast
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@en
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@nl
P2093
P2860
P3181
P356
P1476
The 3'-->5' exonuclease of DNA ...... preventing genome instability
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.091095198
P407
P577
2001-04-17T00:00:00Z