Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
about
Multifunctional Abl kinases in health and diseaseTuberculosis drug discovery in the post-post-genomic eraVaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion exportLow doses of imatinib induce myelopoiesis and enhance host anti-microbial immunityMultiple phosphatidylinositol 3-kinases regulate vaccinia virus morphogenesisA36-dependent actin filament nucleation promotes release of vaccinia virusAttacking pathogens through their hostsSOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune FunctionRNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalizationUnc119 protects from Shigella infection by inhibiting the Abl family kinasesThe Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infectionWIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeuticsArp2/3-mediated actin-based motility: a tail of pathogen abuse.The serine/threonine kinase STK11 promotes Shigella flexneri dissemination through establishment of cell-cell contacts competent for tyrosine kinase signaling.Virus movements on the plasma membrane support infection and transmission between cellsIdentification of polymerase and processivity inhibitors of vaccinia DNA synthesis using a stepwise screening approachF11-mediated inhibition of RhoA signalling enhances the spread of vaccinia virus in vitro and in vivo in an intranasal mouse model of infectionPrimary human macrophages serve as vehicles for vaccinia virus replication and dissemination.Oncolytic vaccinia virus demonstrates antiangiogenic effects mediated by targeting of VEGF.There is an A33-dependent mechanism for the incorporation of B5-GFP into vaccinia virus extracellular enveloped virions.Emerging drugs for varicella-zoster virus infections.Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus.Variola and monkeypox viruses utilize conserved mechanisms of virion motility and release that depend on abl and SRC family tyrosine kinases.Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analoguesToward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomicsThe host phosphoinositide 5-phosphatase SHIP2 regulates dissemination of vaccinia virusSequential therapy with JX-594, a targeted oncolytic poxvirus, followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacySystematic approaches towards the development of host-directed antiviral therapeutics.Development of ST-246® for Treatment of Poxvirus Infections.Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells.Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses.In vitro inhibition of monkeypox virus production and spread by Interferon-β.Basigin is a druggable target for host-oriented antimalarial interventions.Hepatitis C Virus Particle Assembly Involves Phosphorylation of NS5A by the c-Abl Tyrosine Kinase.Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo.Viral interactions with the cytoskeleton: a hitchhiker's guide to the cell.
P2860
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P2860
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@ast
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@en
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@nl
type
label
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@ast
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@en
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@nl
prefLabel
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@ast
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@en
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@nl
P2093
P2860
P356
P1433
P1476
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
@en
P2093
Alyson Swimm
Ann Chahroudi
Bettina Bommarius
Daniel Kalman
Darren Veach
Jens Christensen
Mark B Feinberg
Melanie Sherman
Rahul Chavan
Sarah Lebeis
P2860
P2888
P304
P356
10.1038/NM1265
P407
P577
2005-06-26T00:00:00Z