Understanding organofluorine chemistry. An introduction to the C-F bond
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Methods to Increase the Metabolic Stability of (18)F-RadiotracersInsights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediatesNovel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural AnalysisEvidence That Histidine Protonation of Receptor-Bound Anthrax Protective Antigen Is a Trigger for Pore FormationStructural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine SelectivityFluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNAMapping the Reaction Coordinates of Enzymatic DefluorinationInsights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancersCatalysis for fluorination and trifluoromethylationA Chemical Probe for the ATAD2 BromodomainLate-Stage Fluorination: From Fundamentals to ApplicationSD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrestPositron emission tomography (PET) imaging with (18)F-based radiotracersTwo-Dimensional Fluorinated Graphene: Synthesis, Structures, Properties and ApplicationsSynthetic biology approaches to fluorinated polyketidesAldehyde recognition and discrimination by mammalian odorant receptors via functional group-specific hydration chemistryGUMBOS matrices of variable hydrophobicity for matrix-assisted laser desorption/ionization mass spectrometry.Organic chemistry. A data-intensive approach to mechanistic elucidation applied to chiral anion catalysis.Weak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation.Novel fluorinated ligands for gold nanoparticle labelling with applications in 19F-MRI.Trisubstituted 2-trifluoromethyl pyrrolidines via catalytic asymmetric Michael addition/reductive cyclization.Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.Development of carbon-fluorine spectroscopy for pharmaceutical and biomedical applications.A cell-based, high-throughput homogeneous time-resolved fluorescence assay for the screening of potential κ-opioid receptor agonists.Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxidesSynthesis and Reactivity Studies of α,α-DifluoromethylphosphinatesModelling zwitterions in solution: 3-fluoro-γ-aminobutyric acid (3F-GABA).Facile carbon-fluorine bond activation and subsequent functionalisation of 1,1-difluoroethylene and tetrafluoroethylene promoted by adjacent metal centres.A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging.Propagation rate coefficients for homogeneous phase VDF-HFP copolymerization in supercritical CO2.Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymeraseLong-lived trifluoromethanide anion: a key intermediate in nucleophilic trifluoromethylations.Copper-promoted hydration and annulation of 2-fluorophenylacetylene derivatives: from alkynes to benzo[b]furans and benzo[b]thiophenes.Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinaseInterstrand dipole-dipole interactions can stabilize the collagen triple helix.Monitoring the Stability of Perfluorocarbon Nanoemulsions by Cryo-TEM Image Analysis and Dynamic Light ScatteringAccess to novel fluorovinylidene ligands via exploitation of outer-sphere electrophilic fluorination: new insights into C-F bond formation and activation.Influence of Fluorination on the Conformational Properties and Hydrogen-Bond Acidity of Benzyl Alcohol Derivatives.
P2860
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P2860
Understanding organofluorine chemistry. An introduction to the C-F bond
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Understanding organofluorine chemistry. An introduction to the C-F bond
@ast
Understanding organofluorine chemistry. An introduction to the C-F bond
@en
Understanding organofluorine chemistry. An introduction to the C-F bond
@nl
type
label
Understanding organofluorine chemistry. An introduction to the C-F bond
@ast
Understanding organofluorine chemistry. An introduction to the C-F bond
@en
Understanding organofluorine chemistry. An introduction to the C-F bond
@nl
prefLabel
Understanding organofluorine chemistry. An introduction to the C-F bond
@ast
Understanding organofluorine chemistry. An introduction to the C-F bond
@en
Understanding organofluorine chemistry. An introduction to the C-F bond
@nl
P2860
P356
P1476
Understanding organofluorine chemistry. An introduction to the C-F bond
@en
P2093
David O'Hagan
P2860
P304
P356
10.1039/B711844A
P407
P577
2008-02-01T00:00:00Z