Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis
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Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysisThe human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosisHMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme AInterplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cellsHsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis.Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentationA quarter century of granzymesGranzyme B cleavage of autoantigens in autoimmunityGranzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibitionFragmentation of Golgi complex and Golgi autoantigens during apoptosis and necrosis.Death, autoantigen modifications, and tolerance.GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences.Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis.HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentationInterleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiationGranzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis.Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction.Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.Definition and redesign of the extended substrate specificity of granzyme B.The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Activation of apoptosis and its inhibition.Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin.Caspase-dependent cleavage of nucleic acids.Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection.Familial hemophagocytic lymphohistiocytosis: too little cell death can seriously damage your health.Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolaseAngiostatic effects of NK cell-derived IFN-γ counteracted by tumour cell Bcl-xL expression.Granzyme B-induced mitochondrial ROS are required for apoptosisImplication of caspase-3 and granzyme B expression and activity in spleenocytes of ehrlich ascites carcinoma mice subjected to immunotherapyAltered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage.Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cellsHuman and murine granzyme B exhibit divergent substrate preferences
P2860
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P2860
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@ast
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@en
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@nl
type
label
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@ast
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@en
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@nl
prefLabel
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@ast
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@en
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@nl
P2093
P1433
P1476
Granzyme B directly and effici ...... ions for CTL-induced apoptosis
@en
P2093
D Nicholson
L Casciola-Rosen
N Thornberry
P304
P356
10.1016/S1074-7613(00)80550-6
P407
P577
1998-04-01T00:00:00Z