Human and murine granzyme B exhibit divergent substrate preferences - Test2 - elhamkhani - TriplyDB

Human and murine granzyme B exhibit divergent substrate preferences

Human and murine granzyme B exhibit divergent substrate preferences

http://www.wikidata.org/entity/Q36117776

about

A quarter century of granzymes Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells Preclinical studies identify non-apoptotic low-level caspase-3 as therapeutic target in pemphigus vulgaris The Janus Face of Death Receptor Signaling during Tumor Immunoediting A natural genetic variant of granzyme B confers lethality to a common viral infection Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis.The effector T cell response to influenza infection Proteomic profiling of proteases: tools for granzyme degradomics.Human and mouse granzyme M display divergent and species-specific substrate specificities.Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics.Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity.Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Death by a thousand cuts: granzyme pathways of programmed cell death A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B.Granzyme B-induced mitochondrial ROS are required for apoptosis Mechanisms of granule-dependent killing.The role of serpins in vertebrate immunity.The battlefield of perforin/granzyme cell death pathways.The role of perforin and granzymes in diabetes.A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.Orphan granzymes find a home.Non-cytotoxic antiviral activities of granzymes in the context of the immune antiviral state.Controversies in granzyme biology.Blessing or curse? Proteomics in granzyme research.Brief Exercises Affect Gene Expression in Circulating Monocytes.Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A.Protease signaling in animal and plant-regulated cell death.Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing.Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs.Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway A novel role for granzymes in anti-tumor immunity.Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes.The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing.

P2860

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P2860

Human and murine granzyme B exhibit divergent substrate preferences

http://www.wikidata.org/entity/Q36117776

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Human and murine granzyme B exhibit divergent substrate preferences

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Human and murine granzyme B exhibit divergent substrate preferences

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type

label

Human and murine granzyme B exhibit divergent substrate preferences

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Human and murine granzyme B exhibit divergent substrate preferences

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prefLabel

Human and murine granzyme B exhibit divergent substrate preferences

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Human and murine granzyme B exhibit divergent substrate preferences

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P1433

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P1433

Journal of Cell Biology

P1476

Human and murine granzyme B exhibit divergent substrate preferences

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P2093

Alexander U Lüthi

http://www.w3.org/2001/XMLSchema#string

Patrick J Duriez

http://www.w3.org/2001/XMLSchema#string

Sean P Cullen

http://www.w3.org/2001/XMLSchema#string

P2860

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Human caspase 12 has acquired deleterious mutations

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

The major human and mouse granzymes are structurally and functionally divergent

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

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435-444

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scholarly article

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10.1083/JCB.200612025

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4

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176

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Seamus J. Martin

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2007-02-05T00:00:00Z

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6521922

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17283187

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2063979

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