The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications - Test2 - elhamkhani - TriplyDB

The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications

The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications

http://www.wikidata.org/entity/Q28270728

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Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism.Altered serine/threonine kinase activity in schizophrenia Postmortem brain: an underutilized substrate for studying severe mental illness Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.What is the new target inhibiting the progression of Alzheimer's disease Protein tyrosine phosphatases as potential therapeutic targets.Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking.STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.Dopamine D2 receptors are involved in the regulation of Fyn and metabotropic glutamate receptor 5 phosphorylation in the rat striatum in vivo.Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase,The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity.Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.Rats classified as low or high cocaine locomotor responders: a unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors.Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders.STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit.Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.A common STEP in the synaptic pathology of diverse neuropsychiatric disorders.Lens Biology is a Dimension of Neurobiology.Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia.Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity.X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.Behavioral characterization of striatal-enriched protein tyrosine phosphatase (STEP) knockout mice.NMDA glutamate receptor NR1, NR2A and NR2B expression and NR2B Tyr-1472 phosphorylation in the lens.Use of Peptides for the Management of Alzheimer's Disease: Diagnosis and Inhibition.Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61.

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The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications

http://www.wikidata.org/entity/Q28270728

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2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The tyrosine phosphatase STEP: ...... ying antipsychotic medications

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The tyrosine phosphatase STEP: ...... ying antipsychotic medications

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The tyrosine phosphatase STEP: ...... ying antipsychotic medications

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Translational Psychiatry

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D R Austin

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J Brouillette

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P Kurup

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P R Correa

http://www.w3.org/2001/XMLSchema#string

P Yuan

http://www.w3.org/2001/XMLSchema#string

S M Goebel-Goody

http://www.w3.org/2001/XMLSchema#string

V Haroutunian

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A synaptic model of memory: long-term potentiation in the hippocampus

Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines

Neuregulin 1 and susceptibility to schizophrenia.

Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures

STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum

Regulation of NMDA receptor trafficking by amyloid-beta

Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression

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e137

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2348664

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2

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Christopher Pittenger

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2012-07-10T00:00:00Z

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229063873

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1040040988

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22781170

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