Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA
about
The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldariusMRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repairRAD50 and NBS1 form a stable complex functional in DNA binding and tetheringDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsDNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcaniiAtomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion.The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesMre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break RepairNbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and RepairABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break RepairATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexMre11 and Ku regulation of double-strand break repair by gene conversion and break-induced replication.DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairRAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?Non-homologous end-joining, a sticky affairATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaksTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksThe Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosisInvestigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.An endosomal tether undergoes an entropic collapse to bring vesicles together.A multi-step pathway for the establishment of sister chromatid cohesion.Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationThe ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombinationMRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.Communication between the AAA+ ring and microtubule-binding domain of dynein.Separating DNA with different topologies by atomic force microscopy in comparison with gel electrophoresis.Mechanisms of double-strand break repair in somatic mammalian cells.Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaksBiochemical characterization of bacteriophage T4 Mre11-Rad50 complexThe importance of surfaces in single-molecule bioscience.Molecular basis for SMC rod formation and its dissolution upon DNA bindingATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks.Mechanism and regulation of class switch recombinationCrystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50Recognition and repair of chemically heterogeneous structures at DNA endsEvidence for distinct functions of MRE11 in Arabidopsis meiosis.
P2860
Q21262981-5A648270-4383-489B-B5C3-72573DF90850Q24315682-68CA42DF-C3B8-4034-A670-A37D2FB5ECF5Q24317537-4F684ABD-8B7B-4709-813B-83E2C4A9D730Q24608343-BB790011-AD92-4371-AED1-66978D1EF50AQ24626250-7FB9DE90-CA1B-4826-BF9E-880E1DCBF92FQ24813845-B50A1B8E-4236-46A1-8195-21796A964F33Q27010421-B4FE10BB-21A2-4B2F-8C6D-E9362CAEE94EQ27652502-7C027950-AAD2-476F-AAFA-B3141F965E54Q27657670-97E12F29-92C2-40BE-BF4E-E35EAB424E38Q27667335-BC47D146-B4B9-4BC3-8646-C097EC9BBD7AQ27667404-80026A9D-0EA1-4729-963F-C76D8AB697D1Q27674381-8BB20BF8-B0A7-4390-917F-9BA92E4AE6FFQ27932084-EB0F98AD-15E4-41EA-B9E6-116A6BE38889Q27937081-0A11D1F4-49DE-4CEC-ABBE-2A398A74AF9FQ28085622-A12906FE-3E7A-467E-9536-910A3E99E928Q28239071-26512A7D-BBED-4006-8094-B515CD2B18C6Q28260337-34D22F51-5862-4049-8655-A17C5440A4E9Q28476006-AF8F89BF-D05E-47F4-8C23-89668D7F9434Q28550291-49C9E527-34DC-4060-BF70-E2C6DE00BBD1Q28592328-BE67D3D7-B238-4746-BF08-5F82175B7FCCQ30499891-747271B7-4261-4693-A601-4CC911F1D7B6Q30831126-F1B302B8-A29A-4987-9375-9FCCD99FCBD3Q33269799-B2B24416-9FBC-4DFA-BAB7-559BD56889FFQ33302634-E813B2AD-4E46-4415-8890-866754035B30Q33351069-2F53D8B5-3AC4-4895-8F70-89178EFB5AE7Q33480948-DAD44043-3724-40A5-ABE2-FCD6A1C72ABAQ33569624-C02209C6-588D-4A04-9210-142AF967157CQ33604620-14968963-969A-415D-B15D-22863E8B52A0Q34096816-6AE53E6B-C3CD-498D-9BF7-A0F92D890587Q34237877-636B4E02-ACD6-435B-BF69-6BB7EB7AC854Q34317108-4755DE9D-CDBC-4289-B401-F9480BA80D44Q34432615-8E874A6E-38D4-42F0-88AF-E6452AE29EE1Q34509203-8F5B0DBC-E050-48EF-9868-96747DC8D08FQ34552234-596977A9-474C-49CD-996E-5CDBF96EE04DQ34667318-B0520179-CA37-42FE-857C-9607C2CB57D4Q34722732-E2DB76E7-CFE5-4BD7-A9BD-F1AA05B978CCQ34764888-73CA493E-ED10-4E83-BC22-A3D1F116B919Q34976674-4585D9E5-F15C-4143-997A-B5D8D6126C81Q35002075-A990CF97-E378-4201-B1F1-F49DFAFD6B0AQ35036693-E578A012-D1DC-421D-8B69-7E13A68489E9
P2860
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@ast
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@en
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@nl
type
label
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@ast
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@en
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@nl
prefLabel
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@ast
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@en
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@nl
P2093
P50
P356
P1433
P1476
Mesoscale conformational chang ...... 50/Mre11/Nbs1 upon binding DNA
@en
P2093
Claire Wyman
Martijn de Jager
Roland Kanaar
P2888
P356
10.1038/NATURE03927
P407
P577
2005-09-15T00:00:00Z
P5875
P6179
1048498031