SALL4 is a key transcription regulator in normal human hematopoiesis - Test2 - elhamkhani - TriplyDB

SALL4 is a key transcription regulator in normal human hematopoiesis

SALL4 is a key transcription regulator in normal human hematopoiesis

http://www.wikidata.org/entity/Q28273918

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SALL4, the missing link between stem cells, development and cancer A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes Ex-vivo expansion of nonhuman primate CD34(+) cells by stem cell factor Sall4B Oncofetal gene SALL4 and prognosis in cancer: A systematic review with meta-analysis.Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate.Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner.The characteristic expression pattern of BMI-1 and SALL4 genes in placenta tissue and cord blood Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/β-catenin pathway in esophageal squamous cell carcinoma.Leukemic survival factor SALL4 contributes to defective DNA damage repair.A New Indole Derivative Decreased SALL4 Gene Expression in Acute Promyelocytic Leukemia Cell Line (NB4)Functional and clinical significance of SALL4 in breast cancer.The next new target in leukemia: The embryonic stem cell gene SALL4.Stem cell gene SALL4 in aggressive hepatocellular carcinoma: a cancer stem cell-specific target?The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis SALL4 suppresses PTEN expression to promote glioma cell proliferation via PI3K/AKT signaling pathway.SALL4 as a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis.SALL4 oncogene is an immunogenic antigen presented in various HLA-DR contexts.

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SALL4 is a key transcription regulator in normal human hematopoiesis

http://www.wikidata.org/entity/Q28273918

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2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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SALL4 is a key transcription regulator in normal human hematopoiesis

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Ailing Li

http://www.w3.org/2001/XMLSchema#string

Chong Gao

http://www.w3.org/2001/XMLSchema#string

Daniel G Tenen

http://www.w3.org/2001/XMLSchema#string

Grace S Kao

http://www.w3.org/2001/XMLSchema#string

Hiro Tatetu

http://www.w3.org/2001/XMLSchema#string

Jianchang Yang

http://www.w3.org/2001/XMLSchema#string

Jie He

http://www.w3.org/2001/XMLSchema#string

Li Chai

http://www.w3.org/2001/XMLSchema#string

Nikki R Kong

http://www.w3.org/2001/XMLSchema#string

Shikiko Ueno

http://www.w3.org/2001/XMLSchema#string

P2860

Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family

Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

Novel mutations in the gene SALL4 provide further evidence for acro-renal-ocular and Okihiro syndromes being allelic entities, and extend the phenotypic spectrum

Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice

spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

Okihiro syndrome is caused by SALL4 mutations

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