The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging - Test2 - elhamkhani - TriplyDB

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

http://www.wikidata.org/entity/Q28276378

about

Clinical significance of T cell metabolic reprogramming in cancer Undercover: gene control by metabolites and metabolic enzymes mTOR inhibitors in cancer therapy Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells Raptor regulates functional maturation of murine beta cells.In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis.Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo CC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo.Strategies and Challenges in Clinical Trials Targeting Human Aging.Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice.A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction.TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK.Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats.A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic properties Eukaryotic stand-alone pseudouridine synthases - RNA modifying enzymes and emerging regulators of gene expression?mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?Key proteins and pathways that regulate lifespan.Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Dietary restriction and lifespan: Lessons from invertebrate models.Interaction between epigenetic and metabolism in aging stem cells.Understanding the mTOR signaling pathway via mathematical modeling.Nutrition, metabolism, and targeting aging in nonhuman primates.Nutrient sensing pathways as therapeutic targets for healthy ageing.Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets.Unbalanced Growth, Senescence and Aging.Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity.Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers.Preclinical study of CC223 as a potential anti-ovarian cancer agent.Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy.Aging, Metabolism, and Cancer Development: from Peto's Paradox to the Warburg Effect.Sulfur availability regulates plant growth via glucose-TOR signaling.Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging.Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

http://www.wikidata.org/entity/Q28276378

description

2016 nî lūn-bûn

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2016 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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name

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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J.CMET.2016.05.009

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Cell Metabolism

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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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Brian K Kennedy

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Dudley W Lamming

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Activation of mTORC2 by association with the ribosome

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

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10.1016/J.CMET.2016.05.009

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Dudley W Lamming

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