The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
about
Clinical significance of T cell metabolic reprogramming in cancerUndercover: gene control by metabolites and metabolic enzymesmTOR inhibitors in cancer therapyModerate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in miceRegulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cellsRaptor regulates functional maturation of murine beta cells.In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis.Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivoCC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo.Strategies and Challenges in Clinical Trials Targeting Human Aging.Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice.A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction.TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase ActivityReperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK.Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats.A screening strategy for the discovery of drugs that reduce C/EBPβ-LIP translation with potential calorie restriction mimetic propertiesEukaryotic stand-alone pseudouridine synthases - RNA modifying enzymes and emerging regulators of gene expression?mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?Key proteins and pathways that regulate lifespan.Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Dietary restriction and lifespan: Lessons from invertebrate models.Interaction between epigenetic and metabolism in aging stem cells.Understanding the mTOR signaling pathway via mathematical modeling.Nutrition, metabolism, and targeting aging in nonhuman primates.Nutrient sensing pathways as therapeutic targets for healthy ageing.Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets.Unbalanced Growth, Senescence and Aging.Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity.Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.Clinical Applications of Autophagy Proteins in Cancer: From Potential Targets to Biomarkers.Preclinical study of CC223 as a potential anti-ovarian cancer agent.Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy.Aging, Metabolism, and Cancer Development: from Peto's Paradox to the Warburg Effect.Sulfur availability regulates plant growth via glucose-TOR signaling.Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging.Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.
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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
description
2016 nî lūn-bûn
@nan
2016 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@ast
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@en
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@nl
type
label
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@ast
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@en
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@nl
prefLabel
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@ast
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@en
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@nl
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P1476
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
@en
P2093
Brian K Kennedy
Dudley W Lamming
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P304
P3181
P356
10.1016/J.CMET.2016.05.009
P407
P577
2016-06-14T00:00:00Z