Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
about
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor modelActive-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stressGermline mutations in TMEM127 confer susceptibility to pheochromocytomaPML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTORSuppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycinIdentification of Protor as a novel Rictor-binding component of mTOR complex-2mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideMammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveRab1A is an mTORC1 activator and a colorectal oncogeneThe target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathwaymTORC2 phosphorylates protein kinase Cζ to regulate its stability and activityA new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingPRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcriptionDistinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Signaling by target of rapamycin proteins in cell growth controlNutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationThe TOR pathway comes of ageMammalian target of rapamycin: a central node of complex signaling cascadesPotential use of rapamycin in HIV infectionUpdates of mTOR inhibitorsmTOR inhibitors in advanced renal cell carcinomaRole of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksSpatial regulation of the mTORC1 system in amino acids sensing pathwayTargeting mTOR for the treatment of AML. New agents and new directionsPushing the envelope in the mTOR pathway: the second generation of inhibitorsThe mTOR signalling pathway in human cancerThe tuberous sclerosis complexNext-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategyAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyAkt and autophagy cooperate to promote survival of drug-resistant gliomaFoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and RictorTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyRictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cellsTti1 and Tel2 are critical factors in mammalian target of rapamycin complex assemblymTOR: from growth signal integration to cancer, diabetes and ageingmTOR signaling in growth control and disease
P2860
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P2860
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@ast
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@en
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@nl
type
label
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@ast
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@en
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@nl
prefLabel
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@ast
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@en
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@nl
P2093
P50
P3181
P1433
P1476
Rictor, a novel binding partne ...... hat regulates the cytoskeleton
@en
P2093
D D Sarbassov
David A Guertin
David M Sabatini
Robert R Latek
Siraj M Ali
P304
P3181
P356
10.1016/J.CUB.2004.06.054
P407
P577
2004-07-27T00:00:00Z