Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction
about
Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand RecognitionA deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKPUnifying concepts in CD28, ICOS and CTLA4 co-receptor signallingThe C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motifCD28 and CTLA-4 coreceptor expression and signal transductionQuantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src.Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signalingSignal transduction via CD44: role of plasma membrane microdomains.An enigmatic tail of CD28 signaling.Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulationNovel role for p21-activated kinase 2 in thrombin-induced monocyte migration.PD-1 signaling in primary T cellsCD28 co-signaling in the adaptive immune response.Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278).CD28 Costimulation: From Mechanism to Therapy.Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression.Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors.Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation.A point mutation in CD28 distinguishes proliferative signals from survival signals.Grb2 binds CD28
P2860
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P2860
Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@ast
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@en
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@nl
type
label
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@ast
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@en
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@nl
prefLabel
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@ast
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@en
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@nl
P2860
P356
P1476
Grb2 forms an inducible protei ...... y 3 domain-proline interaction
@en
P2860
P304
P356
10.1074/JBC.273.33.21194
P407
P577
1998-08-14T00:00:00Z