about
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferationIg gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerancePhosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damageRequirement of bic/microRNA-155 for normal immune functionOncogenic PI3Kα promotes multipotency in breast epithelial cellsPI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)Gene targeting in mice: a reviewPI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancerSequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophilsEvidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null miceGrb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interactionSignaling by the phosphoinositide 3-kinase family in immune cellsEssential role for the p110delta phosphoinositide 3-kinase in the allergic responsePhosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reactionPI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levelsCritical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulationThe PI3K p110δ regulates expression of CD38 on regulatory T cellsTargeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapyCCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathwayFirefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells.Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte traffickingCellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allograftsNew responsibilities for the PI3K regulatory subunit p85 alpha.Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells.Phosphoinositide 3-kinase in T cell activation and survival.PI3Ks in lymphocyte signaling and developmentInhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production.Two birds with one stone: dual p110δ and p110γ inhibitionA protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells.Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation.The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic DiseasesT cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice.The transcription factor BACH2 promotes tumor immunosuppression.The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancersIonic immune suppression within the tumour microenvironment limits T cell effector function.
P50
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Klaus Okkenhaug
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Klaus Okkenhaug
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Klaus Okkenhaug
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Klaus Okkenhaug
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Klaus Okkenhaug
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Klaus Okkenhaug
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Klaus Okkenhaug
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Klaus Okkenhaug
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