Oncogenic mechanisms of the Helicobacter pylori CagA protein - Test2 - elhamkhani - TriplyDB

Oncogenic mechanisms of the Helicobacter pylori CagA protein

Oncogenic mechanisms of the Helicobacter pylori CagA protein

http://www.wikidata.org/entity/Q28280246

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Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination Mechanisms of disease: Helicobacter pylori virulence factors Pathogenesis of Helicobacter pylori infection Helicobacter pylori and gastroduodenal pathology: new threats of the old friend Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability.Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England.Role of Helicobacter pylori in gastric cancer: Updates Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis Helicobacter pylori in gastric carcinogenesis: mechanisms Effect of Helicobacter pylori on gastric epithelial cells Functional regulation of phospholipase D expression in cancer and inflammation Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography Helicobacter and salmonella persistent infection strategies An Update on Helicobacter pylori as the Cause of Gastric Cancer Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease Bacterial phosphoproteomic analysis reveals the correlation between protein phosphorylation and bacterial pathogenicity The Helicobacter pylori cag Pathogenicity Island Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Structural insights into Helicobacter pylori oncoprotein CagA interaction with 1 integrin Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2 Pathogenesis and risk factors for gastric cancer after Helicobacter pylori eradication H pylori and gastric cancer: shifting the global burden Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis Helicobacter pylori and gastric cancer: the causal relationship A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.Higher frequency of cagA EPIYA-C phosphorylation sites in H. pylori strains from first-degree relatives of gastric cancer patients.The effect of the cag pathogenicity island on binding of Helicobacter pylori to gastric epithelial cells and the subsequent induction of apoptosis.Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability.Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner Distinguishing potential bacteria-tumor associations from contamination in a secondary data analysis of public cancer genome sequence data.Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island Ancestral European roots of Helicobacter pylori in India.Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer.Expression of Helicobacter pylori CagA domains by library-based construct screening.Analysis of virulence factors of Helicobacter pylori isolated from a Vietnamese population A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori.Targeting PTPs with small molecule inhibitors in cancer treatment

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Nature Reviews Cancer

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

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Masanori Hatakeyama

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P2860

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility

Crystal structure of the tyrosine phosphatase SHP-2

Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori

Helicobacter pylori infection and the development of gastric cancer

c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs.

SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.

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10.1038/NRC1433

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Helicobacter pylori