about
Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress responseEngineering large animal models of human diseaseThe structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulatorLow concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activityUtrophin up-regulation by an artificial transcription factor in transgenic miceAn engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes.Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactionsTargets for future clinical trials in Huntington's disease: what's in the pipeline?Effect of His-Tag on Expression, Purification, and Structure of Zinc Finger Protein, ZNF191(243-368)Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cellsThe multi-zinc finger protein ZNF217 contacts DNA through a two-finger domainSequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylaseAdvances in phage display technology for drug discovery.Altered regulation of beta-like globin genes by a redesigned erythroid transcription factorThe DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells.Targeting the absence: homozygous DNA deletions as immutable signposts for cancer therapy.Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factorMitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.The approaches for manipulating mitochondrial proteomeTowards artificial metallonucleases for gene therapy: recent advances and new perspectives.Cell Biology Symposium: Zinc finger nucleases to create custom-designed modifications in the swine (Sus scrofa) genome.A systems-level approach for metabolic engineering of yeast cell factories.Molecular scissors for in situ cellular repair.Crosstalk between endogenous and synthetic components--synthetic signaling meets endogenous components.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Beyond the Fold: Emerging Biological Applications of DNA Origami.Huntington's disease: Molecular basis of pathology and status of current therapeutic approachesTowards computational specificity screening of DNA-binding proteins[Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O is 2,6-dipicolinate and N,O is L-threoninate: synthesis, characterization, and biomedical properties.The simple and rapid detection of specific PCR products from bacterial genomes using Zn finger proteins.Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.Stability and folding behavior analysis of zinc-finger using simple models.Rational design of an estrogen receptor mutant with altered DNA-binding specificity.Characterization of the cofactor-induced folding mechanism of a zinc-binding peptide using computationally designed mutants.Light-activated gene editing with a photocaged zinc-finger nuclease.Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Designer zinc-finger proteins and their applications
@ast
Designer zinc-finger proteins and their applications
@de
Designer zinc-finger proteins and their applications
@en
Designer zinc-finger proteins and their applications
@fr
Designer zinc-finger proteins and their applications
@nl
type
label
Designer zinc-finger proteins and their applications
@ast
Designer zinc-finger proteins and their applications
@de
Designer zinc-finger proteins and their applications
@en
Designer zinc-finger proteins and their applications
@fr
Designer zinc-finger proteins and their applications
@nl
prefLabel
Designer zinc-finger proteins and their applications
@ast
Designer zinc-finger proteins and their applications
@de
Designer zinc-finger proteins and their applications
@en
Designer zinc-finger proteins and their applications
@fr
Designer zinc-finger proteins and their applications
@nl
P2093
P3181
P1433
P1476
Designer zinc-finger proteins and their applications
@en
P2093
Michal Minczuk
Monika Papworth
Paulina Kolasinska
P3181
P356
10.1016/J.GENE.2005.09.011
P407
P577
2006-01-17T00:00:00Z