Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
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Epigenetic mechanisms in drug addictionEnabling functional genomics with genome engineeringStrategies for precision modulation of gene expression by epigenome editing: an overviewEpigenome engineering in cancer: fairytale or a realistic path to the clinic?Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtypeThe epigenome: the next substrate for engineeringCRISPR-Mediated Epigenome EditingChromatin regulation at the frontier of synthetic biologyA controllable on-off strategy for the reproductive containment of fishTargeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cellsTailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae.Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.Aberrant epigenetic silencing is triggered by a transient reduction in gene expressionTargeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase.Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells.C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.Complementation between inactive fragments of SssI DNA methyltransferase.Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers.Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small moleculesCurrent and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer.Transcription factors and molecular epigenetic marks underlying EpCAM overexpression in ovarian cancerDirected evolution of improved zinc finger methyltransferases.Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.Epigenetic reprogramming of cancer cells via targeted DNA methylation.Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer.The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors.Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes.DNA methylation in schizophrenia: progress and challenges of epigenetic studiesThe triple helix: 50 years later, the outcome.The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.Repurposing the CRISPR-Cas9 system for targeted DNA methylation.Epigenomics of hypertensionTranscriptional silencing and reactivation in transgenic zebrafish.Histone acetylation in drug addiction.Cas9-based tools for targeted genome editing and transcriptional control.Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1.Advanced Gene Manipulation Methods for Stem Cell Theranostics.Site-specific methylated reporter constructs for functional analysis of DNA methylation.Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity
P2860
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P2860
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Chimeric DNA methyltransferase ...... ss expression of target genes.
@en
type
label
Chimeric DNA methyltransferase ...... ss expression of target genes.
@en
prefLabel
Chimeric DNA methyltransferase ...... ss expression of target genes.
@en
P2093
P2860
P356
P1476
Chimeric DNA methyltransferase ...... ess expression of target genes
@en
P2093
Christian Rohde
Monika Papworth
Sergei Ragozin
Yingying Zhang
P2860
P304
P356
10.1093/NAR/GKL1035
P577
2006-12-06T00:00:00Z