Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. - Test2 - elhamkhani - TriplyDB

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.

http://www.wikidata.org/entity/Q40199783

about

Epigenetic mechanisms in drug addiction Enabling functional genomics with genome engineering Strategies for precision modulation of gene expression by epigenome editing: an overview Epigenome engineering in cancer: fairytale or a realistic path to the clinic?Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype The epigenome: the next substrate for engineering CRISPR-Mediated Epigenome Editing Chromatin regulation at the frontier of synthetic biology A controllable on-off strategy for the reproductive containment of fish Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells Tailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae.Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.Aberrant epigenetic silencing is triggered by a transient reduction in gene expression Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase.Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells.C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.Complementation between inactive fragments of SssI DNA methyltransferase.Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers.Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small molecules Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer.Transcription factors and molecular epigenetic marks underlying EpCAM overexpression in ovarian cancer Directed evolution of improved zinc finger methyltransferases.Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.Epigenetic reprogramming of cancer cells via targeted DNA methylation.Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer.The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors.Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes.DNA methylation in schizophrenia: progress and challenges of epigenetic studies The triple helix: 50 years later, the outcome.The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.Repurposing the CRISPR-Cas9 system for targeted DNA methylation.Epigenomics of hypertension Transcriptional silencing and reactivation in transgenic zebrafish.Histone acetylation in drug addiction.Cas9-based tools for targeted genome editing and transcriptional control.Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1.Advanced Gene Manipulation Methods for Stem Cell Theranostics.Site-specific methylated reporter constructs for functional analysis of DNA methylation.Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity

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P2860

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.

http://www.wikidata.org/entity/Q40199783

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

@zh-tw

2006年论文

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2006年论文

@zh

2006年论文

@zh-cn

name

Chimeric DNA methyltransferase ...... ss expression of target genes.

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type

label

Chimeric DNA methyltransferase ...... ss expression of target genes.

@en

prefLabel

Chimeric DNA methyltransferase ...... ss expression of target genes.

@en

P1433

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P1433

Nucleic Acids Research

P1476

Chimeric DNA methyltransferase ...... ess expression of target genes

@en

P2093

Christian Rohde

http://www.w3.org/2001/XMLSchema#string

Fuyang Li

http://www.w3.org/2001/XMLSchema#string

Monika Papworth

http://www.w3.org/2001/XMLSchema#string

Sergei Ragozin

http://www.w3.org/2001/XMLSchema#string

Yingying Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

DNA methylation patterns and epigenetic memory

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells

The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells

Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

Myc represses transcription through recruitment of DNA methyltransferase corepressor

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

P304

100-112

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P31

scholarly article

P356

10.1093/NAR/GKL1035

http://www.w3.org/2001/XMLSchema#string

P433

1

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P478

35

http://www.w3.org/2001/XMLSchema#string

P50

Michał Mińczuk

P577

2006-12-06T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6648494

http://www.w3.org/2001/XMLSchema#string

P698

17151075

http://www.w3.org/2001/XMLSchema#string

P921

DNA methylation

P932

1761428

http://www.w3.org/2001/XMLSchema#string