The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells
about
Long non-coding RNAs as regulators of the endocrine systemInactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells.Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heartMalate-aspartate shuttle inhibitor aminooxyacetic acid blocks lipopolysaccharides-induced activation of BV2 microgliaAtaxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cellsRegulation of insulin secretion: role of mitochondrial signalling.Malate-aspartate shuttle mediates the intracellular ATP levels, antioxidation capacity and survival of differentiated PC12 cells.Glucose sensing in the pancreatic beta cell: a computational systems analysis.Comparative Analysis of the Mitochondrial Physiology of Pancreatic β CellsTopological organization of multichromosomal regions by the long intergenic noncoding RNA FirreProtection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation.Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.Aralar plays a significant role in maintaining the survival and mitochondrial membrane potential of BV2 microglia.Frex and FrexH: Indicators of metabolic states in living cells.The presence of 1 mM glycine in vitrification solutions protects oocyte mitochondrial homeostasis and improves blastocyst development.Mitochondrial transporters as novel targets for intracellular calcium signaling.Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster.Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.Hypoxia induces a HIF-1α dependent signaling cascade to make a complex metabolic switch in SGBS-adipocytes.The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: physiological links and abnormalities in autism.The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells.Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity.Local and regional control of calcium dynamics in the pancreatic islet.Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1.Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.A kinetic core model of the glucose-stimulated insulin secretion network of pancreatic beta cells.Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion.Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.
P2860
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P2860
The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
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name
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@ast
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@en
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@nl
type
label
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@ast
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@en
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@nl
prefLabel
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@ast
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@en
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@nl
P2860
P50
P921
P356
P1476
The malate-aspartate NADH shut ...... nsulin secretion in beta cells
@en
P2093
Blanca Rubi
Clarissa Bartley
P2860
P304
55659-55666
P356
10.1074/JBC.M409303200
P407
P577
2004-10-19T00:00:00Z