about
Therapeutic Strategies for Neuropathic Pain: Potential Application of Pharmacosynthetics and OptogeneticsSynthetic biology approaches to engineer T cellsNew insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsDREADDs: novel tools for drug discovery and developmentOptogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuitsPreclinical models for obesity researchPharmacosynthetics: Reimagining the pharmacogenetic approachStructure and function of serotonin G protein-coupled receptors.Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia.Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptorsA synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cellsInducible and titratable silencing of Caenorhabditis elegans neurons in vivo with histamine-gated chloride channelsSynthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal.Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs.Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP SignalingEukaryotic systems broaden the scope of synthetic biology.Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling.Rational Redesign of a Functional Protein Kinase-Substrate Interaction.Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formationMolecular genetics and imaging technologies for circuit-based neuroanatomy.Cell-type specific regulation of cortical excitability through the allatostatin receptor system.Modular extracellular sensor architecture for engineering mammalian cell-based devices.Biology by design: from top to bottom and backTransgenic mice: beyond the knockoutStructure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitizationRemote control of neuronal signaling.Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptorPhysiologic and anatomic characterization of the brain surface glia barrier of DrosophilaThe Role of Th17 in Neuroimmune Disorders: A Target for CAM Therapy. Part IIIGs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.Striatal microcircuitry and movement disordersActivated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.Modulating and evaluating receptor promiscuity through directed evolution and modeling.A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.DREADDs for Neuroscientists.Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Engineering GPCR signaling pathways with RASSLs
@ast
Engineering GPCR signaling pathways with RASSLs
@en
Engineering GPCR signaling pathways with RASSLs
@nl
type
label
Engineering GPCR signaling pathways with RASSLs
@ast
Engineering GPCR signaling pathways with RASSLs
@en
Engineering GPCR signaling pathways with RASSLs
@nl
prefLabel
Engineering GPCR signaling pathways with RASSLs
@ast
Engineering GPCR signaling pathways with RASSLs
@en
Engineering GPCR signaling pathways with RASSLs
@nl
P2093
P2860
P356
P1433
P1476
Engineering GPCR signaling pathways with RASSLs
@en
P2093
Aline Dumuis
Bruce R Conklin
Bryan L Roth
Edward C Hsiao
Jean-Marc Guettier
John R Forsayeth
Jürgen Wess
Ken D McCarthy
Robert A Nissenson
Supriya Srinivasan
P2860
P2888
P356
10.1038/NMETH.1232
P407
P577
2008-08-01T00:00:00Z
P5875
P6179
1044874264