New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors
about
Opportunities for functional selectivity in GPCR antibodiesThe role of experimental and computational structural approaches in 7TM drug discovery.Limits of ligand selectivity from docking to models: in silico screening for A(1) adenosine receptor antagonistsDevelopment of 7TM receptor-ligand complex models using ligand-biased, semi-empirical helix-bundle repacking in torsion space: application to the agonist interaction of the human dopamine D2 receptor.Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.Computational studies to predict or explain G protein coupled receptor polypharmacologyFulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules.Ligand interaction, binding site and G protein activation of the mu opioid receptorNew paradigms in GPCR drug discovery.Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mCrystal structures of the A2A adenosine receptor and their use in medicinal chemistry.X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?Structure-based and fragment-based GPCR drug discovery.Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.The receptor concept in 3D: from hypothesis and metaphor to GPCR-ligand structures.New Trends in Inspecting GPCR-ligand Recognition Process: the Contribution of the Molecular Modeling Section (MMS) at the University of Padova.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.G protein-coupled receptors: computer-aided ligand discovery and computational structural analyses in the 2010s.Graph analysis of β2 adrenergic receptor structures: a "social network" of GPCR residues.Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors.The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site.Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracySelective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants.Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures.Docking studies for melatonin receptors.Apelinergic System Structure and Function.Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor
P2860
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P2860
New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
New insights for drug design f ...... of G-protein-coupled receptors
@ast
New insights for drug design f ...... of G-protein-coupled receptors
@en
New insights for drug design f ...... of G-protein-coupled receptors
@nl
type
label
New insights for drug design f ...... of G-protein-coupled receptors
@ast
New insights for drug design f ...... of G-protein-coupled receptors
@en
New insights for drug design f ...... of G-protein-coupled receptors
@nl
prefLabel
New insights for drug design f ...... of G-protein-coupled receptors
@ast
New insights for drug design f ...... of G-protein-coupled receptors
@en
New insights for drug design f ...... of G-protein-coupled receptors
@nl
P2860
P356
P1476
New insights for drug design f ...... of G-protein-coupled receptors
@en
P2093
K. A. Jacobson
S. Costanzi
P2860
P304
P356
10.1124/MOL.112.079335
P407
P577
2012-09-01T00:00:00Z